WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406715
CAS#: 64232-83-3
Description: L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ). L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
MedKoo Cat#: 406715
Name: L189
CAS#: 64232-83-3
Chemical Formula: C11H10N4OS
Exact Mass: 246.05753
Molecular Weight: 246.29
Elemental Analysis: C, 53.64; H, 4.09; N, 22.75; O, 6.50; S, 13.02
Synonym: L189; L 189; L-189.
IUPAC/Chemical Name: (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChi Key: SAKOXVNKDMWWLF-AWNIVKPZSA-N
InChi Code: InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)/b13-6+
SMILES Code: O=C(C(/N=C/C1=CC=CC=C1)=C(N)N2)NC2=S
1: Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD Jr, Tomkinson AE. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair. Cancer Res. 2008 May 1;68(9):3169-77. doi: 10.1158/0008-5472.CAN-07-6636. PubMed PMID: 18451142; PubMed Central PMCID: PMC2734474.
