GAT100

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522513

CAS#: 1663564-42-8

Description: GAT100 is a potent and covalent negative allosteric modulator (NAM). GAT-100 behaved as a robust positive allosteric modulator of binding of orthosteric agonist CP55,940. This novel covalent probe can serve as a useful tool for characterizing CB1R allosteric ligand-binding motifs.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-03-29. Prices are subject to change without notice.

GAT100 is not in stock, but may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 522513
Name: GAT100
CAS#: 1663564-42-8
Chemical Formula: C25H28N4OS
Exact Mass: 432.1983
Molecular Weight: 432.59
Elemental Analysis: C, 69.41; H, 6.52; N, 12.95; O, 3.70; S, 7.41


Synonym: GAT100; GAT-100; GAT 100.

IUPAC/Chemical Name: 3-ethyl-5-isothiocyanato-N-(4-(piperidin-1-yl)phenethyl)-1H-indole-2-carboxamide

InChi Key: YIYLMDVRSNXYOT-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28N4OS/c1-2-21-22-16-19(27-17-31)8-11-23(22)28-24(21)25(30)26-13-12-18-6-9-20(10-7-18)29-14-4-3-5-15-29/h6-11,16,28H,2-5,12-15H2,1H3,(H,26,30)

SMILES Code: O=C(C(N1)=C(CC)C2=C1C=CC(N=C=S)=C2)NCCC3=CC=C(N4CCCCC4)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright
EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA.
Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid
1 Receptor Allosteric Site(s). J Med Chem. 2015 Nov 28. [Epub ahead of print]
PubMed PMID: 26529344.