WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 318868
CAS#: 33005-95-7
Description: Tiaprofenic acid is a non-steroidal anti-inflammatory drug (NSAID) of the arylpropionic acid (profen) class, used to treat pain, especially arthritic pain Long-term use of tiaprofenic acid is associated with severe cystitis, roughly 100 times more commonly than other NSAIDs. It is contraindicated in patients with cystitis and urinary tract infections.
MedKoo Cat#: 318868
Name: Tiaprofenic acid
CAS#: 33005-95-7
Chemical Formula: C14H12O3S
Exact Mass: 260.0507
Molecular Weight: 260.307
Elemental Analysis: C, 64.60; H, 4.65; O, 18.44; S, 12.32
Synonym: Tiaprofenic acid; trade names Surgam, Surgamyl and Tiaprofen.
IUPAC/Chemical Name: 2-(5-benzoyl-2-thienyl)propanoic acid
InChi Key: GUHPRPJDBZHYCJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H12O3S/c1-9(14(16)17)11-7-8-12(18-11)13(15)10-5-3-2-4-6-10/h2-9H,1H3,(H,16,17)
SMILES Code: CC(C1=CC=C(C(C2=CC=CC=C2)=O)S1)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 260.307 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Moore RA, Derry S, Moore M, McQuay HJ. Single dose oral tiaprofenic acid for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD007542. doi: 10.1002/14651858.CD007542.pub2. Review. PubMed PMID: 19821426; PubMed Central PMCID: PMC4170996.
2: Andreassen KH, Eldrup J, Hansen RI, Oster S. Tiaprofenic acid-induced cystitis--three cases and a literature review. Scand J Urol Nephrol. 1999 Dec;33(6):408-10. Review. PubMed PMID: 10636583.
3: Crew JP, Donat R, Roskell D, Fellows GJ. Bilateral ureteric obstruction secondary to the prolonged use of tiaprofenic acid. Br J Clin Pract. 1997 Jan-Feb;51(1):59-60. Review. PubMed PMID: 9158277.
4: Davies NM. Clinical pharmacokinetics of tiaprofenic acid and its enantiomers. Clin Pharmacokinet. 1996 Nov;31(5):331-47. Review. PubMed PMID: 9118583.
5: Plosker GL, Wagstaff AJ. Tiaprofenic acid. A reappraisal of its pharmacological properties and use in the management of rheumatic diseases. Drugs. 1995 Dec;50(6):1050-75. Review. PubMed PMID: 8612471.
6: Famaey JP. Symposium on therapeutic aspects of tiaprofenic acid. Drugs. 1988;35 Suppl 1:1-3. Review. PubMed PMID: 3282866.
7: Sorkin EM, Brogden RN. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs. 1985 Mar;29(3):208-35. Review. PubMed PMID: 3886353.
8: Poletto B. Tiaprofenic acid. Clin Rheum Dis. 1984 Aug;10(2):333-51. Review. PubMed PMID: 6391794.
