Bambuterol Hydrochloride
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MedKoo CAT#: 317309

CAS#: 81732-46-9

Description: Bambuterol Hydrochloride is a long acting beta-adrenoceptor agonist used in the treatment of asthma. Bambuterol Hydrochloride acts as a bronchodilator. It inhibits plasma BChE (cholinesterase) during metabolism prolongs suxamethonium-induced neuromuscular blockade.


Chemical Structure

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Bambuterol Hydrochloride
CAS# 81732-46-9

Theoretical Analysis

MedKoo Cat#: 317309
Name: Bambuterol Hydrochloride
CAS#: 81732-46-9
Chemical Formula: C18H30ClN3O5
Exact Mass: 0.00
Molecular Weight: 403.900
Elemental Analysis: C, 53.53; H, 7.49; Cl, 8.78; N, 10.40; O, 19.81

Price and Availability

Size Price Availability Quantity
1g USD 275 2 Weeks
2g USD 450
5g USD 950 2 Weeks
10g USD 1650 2 Weeks
Bulk inquiry

Synonym: Bambuterol Hydrochloride; UNII-Y1850G1OVC; Bambuterol HCl; CHEBI:59167;DSSTox_CID_25515

IUPAC/Chemical Name: [3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate;hydrochloride

InChi Key: LBARATORRVNNQM-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H29N3O5.ClH/c1-18(2,3)19-11-15(22)12-8-13(25-16(23)20(4)5)10-14(9-12)26-17(24)21(6)7;/h8-10,15,19,22H,11H2,1-7H3;1H

SMILES Code: CC(C)(C)NCC(C1=CC(=CC(=C1)OC(=O)N(C)C)OC(=O)N(C)C)O.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Bambuterol hydrochloride is a long acting beta-adrenoceptor agonist (LABA) used in the treatment of asthma.
In vitro activity: In vitro, bath-applied bambuterol (1-100 microm) and tetraisopropylpyrophosphoramide (10-100 microm) decreased BChE activity in the brainstem but did not perturb central respiratory activity recorded from spinal nerve rootlets. Reference: Eur J Neurosci. 2003 Sep;18(6):1419-27. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.2003.02867.x?sid=nlm%3Apubmed
In vivo activity: The effects of bambuterol (Bam) on bronchoconstriction in guinea pigs were studied. Bam dose-dependently prolonged the time to histamine-induced collapse. Bam 2 or 10 mg.kg-1 i.g. 2 h before ovalbumin aerosol partly or almost completely inhibited bronchial challenge of ovalbumin-induced change of RL and Cdyn. Bam 0.1-1.0 mumol.L-1 gave a weak relaxation on isolated tracheal strips induced by carbamylcholine and failed to relax the isolated resting lung parenchyma strips in guinea pig. Overall, Bam showed a long-acting bronchodilation by its slow metabolism in vivo. Reference: Zhongguo Yao Li Xue Bao. 1999 Jul;20(7):651-4. https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.2003.02867.x?sid=nlm%3Apubmed

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 100.0 247.59
Water 41.2 102.01
Ethanol 8.0 19.81
PBS (pH 7.2) 10.0 24.76

Preparing Stock Solutions

The following data is based on the product molecular weight 403.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Chatonnet F, Boudinot E, Chatonnet A, Taysse L, Daulon S, Champagnat J, Foutz AS. Respiratory survival mechanisms in acetylcholinesterase knockout mouse. Eur J Neurosci. 2003 Sep;18(6):1419-27. doi: 10.1046/j.1460-9568.2003.02867.x. PMID: 14511322. 2. Xie QM, Zeng LH, Zheng YX, Lu YB, Yang QH. Bronchodilating effects of bambuterol on bronchoconstriction in guinea pigs. Zhongguo Yao Li Xue Bao. 1999 Jul;20(7):651-4. PMID: 10678133.
In vitro protocol: 1. Chatonnet F, Boudinot E, Chatonnet A, Taysse L, Daulon S, Champagnat J, Foutz AS. Respiratory survival mechanisms in acetylcholinesterase knockout mouse. Eur J Neurosci. 2003 Sep;18(6):1419-27. doi: 10.1046/j.1460-9568.2003.02867.x. PMID: 14511322.
In vivo protocol: 1. Chatonnet F, Boudinot E, Chatonnet A, Taysse L, Daulon S, Champagnat J, Foutz AS. Respiratory survival mechanisms in acetylcholinesterase knockout mouse. Eur J Neurosci. 2003 Sep;18(6):1419-27. doi: 10.1046/j.1460-9568.2003.02867.x. PMID: 14511322. 2. Xie QM, Zeng LH, Zheng YX, Lu YB, Yang QH. Bronchodilating effects of bambuterol on bronchoconstriction in guinea pigs. Zhongguo Yao Li Xue Bao. 1999 Jul;20(7):651-4. PMID: 10678133.

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19: Yanamandra R, Vadla CS, Puppala UM, Patro B, Murthy YL, Parimi AR.
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