Butoconazole Nitrate
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 317362

CAS#: 64872-77-1

Description: Butoconazole is an imidazole antifungal used in gynecology. It is administered as a vaginal cream.


Chemical Structure

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Butoconazole Nitrate
CAS# 64872-77-1

Theoretical Analysis

MedKoo Cat#: 317362
Name: Butoconazole Nitrate
CAS#: 64872-77-1
Chemical Formula: C19H18Cl3N3O3S
Exact Mass: 0.00
Molecular Weight: 474.781
Elemental Analysis: C, 48.07; H, 3.82; Cl, 22.40; N, 8.85; O, 10.11; S, 6.75

Price and Availability

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1g USD 350 2 Weeks
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Synonym: Butoconazole, Gynazole-1, Mycelex-3, RS35887, RS-35887, RS 35887; Butoconazole Nitrate

IUPAC/Chemical Name: 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole nitrate

InChi Key: ZHPWRQIPPNZNML-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4)

SMILES Code: ClC1=C(SC(CCC2=CC=C(Cl)C=C2)CN3C=CN=C3)C(Cl)=CC=C1.O[N+]([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 474.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tatum DM, Eggleston M. Butoconazole nitrate. Infect Control Hosp Epidemiol. 1988 Mar;9(3):122-4. doi: 10.1086/645809. PMID: 3280665.


2: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Butoconazole. 2018 Oct 31. PMID: 30000484.


3: Ţuchiu BM, Staden RS, van Staden JKF, Aboul-Enein HY. N-Methylfulleropyrrolidine-Based Multimode Sensor for Determination of Butoconazole Nitrate. ACS Omega. 2022 Nov 8;7(46):42537-42544. doi: 10.1021/acsomega.2c05904. PMID: 36440171; PMCID: PMC9685749.


4: Lappin MA, Brooker DC, Francisco CA, Dorfman J. Effect of butoconazole nitrate 2% vaginal cream and miconazole nitrate 2% vaginal cream treatments in patients with vulvovaginal candidiasis. Infect Dis Obstet Gynecol. 1996;4(6):323-8. doi: 10.1155/S1064744996000658. PMID: 18476119; PMCID: PMC2364522.


5: Ruf H, Vitse M. A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. J Int Med Res. 1990 Sep-Oct;18(5):389-99. doi: 10.1177/030006059001800507. PMID: 2257961.


6: Seidman LS, Skokos CK. An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis. Infect Dis Obstet Gynecol. 2005 Dec;13(4):197-206. doi: 10.1080/10647440500240615. PMID: 16338779; PMCID: PMC1784583.


7: Brown D, Henzl MR, Kaufman RH. Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group. J Reprod Med. 1999 Nov;44(11):933-8. PMID: 10589403.


8: Jacobson JB, Hajman AJ, Wiese J, Gandrup P, Forsström S. A new vaginal antifungal agent--butoconazole nitrate. Acta Obstet Gynecol Scand. 1985;64(3):241-4. doi: 10.3109/00016348509155121. PMID: 3893024.


9: Sayed RA, Elmasry MS, Hassan WS, El-Mammli MY, Shalaby A. Development and application of degradation kinetics of thin layer chromatographic densitometry and conductometric methods for butoconazole nitrate determination. Ann Pharm Fr. 2018 Nov;76(6):453-463. doi: 10.1016/j.pharma.2018.07.007. Epub 2018 Aug 29. PMID: 30172352.


10: Brown D Jr, Henzl MR, LePage ME, Tsao LL, Izu AE, Walker KA, Adamson GD, Droegmuller W. Butoconazole vaginal cream in the treatment of vulvovaginal candidiasis. Comparison with miconazole nitrate and placebo. J Reprod Med. 1986 Nov;31(11):1045-8. PMID: 3543342.


11: Droegemueller W, Adamson DG, Brown D, Cibley L, Fleury F, LePage ME, Henzl MR. Three-day treatment with butoconazole nitrate for vulvovaginal candidiasis. Obstet Gynecol. 1984 Oct;64(4):530-4. PMID: 6384848.


12: Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY. Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):431-436. doi: 10.1007/s11596-014-1296-y. Epub 2014 Jun 18. PMID: 24939312.


13: Hajman AJ. Vulvovaginal candidosis: comparison of 3-day treatment with 2% butoconazole nitrate cream and 6-day treatment with 1% clotrimazole cream. J Int Med Res. 1988 Sep-Oct;16(5):367-75. doi: 10.1177/030006058801600506. PMID: 3197914.


14: Bradbeer CS, Mayhew SR, Barlow D. Butoconazole and miconazole in treating vaginal candidiasis. Genitourin Med. 1985 Aug;61(4):270-2. doi: 10.1136/sti.61.4.270. PMID: 3894216; PMCID: PMC1011829.


15: Weinstein L, Henzel MR, Tsina IW. Vaginal retention of 2% butoconazole nitrate cream: comparison of a standard and a sustained-release preparation. Clin Ther. 1994 Nov-Dec;16(6):930-4. PMID: 7697689.


16: Adamson GD. Three-day treatment of vulvovaginal candidiasis. Am J Obstet Gynecol. 1988 Apr;158(4):1002-5. doi: 10.1016/0002-9378(88)90114-7. PMID: 3364485.


17: Kaufman RH, Henzl MR, Brown D Jr, Horner DS, Krauss RH, Mehlisch DR, Moore DE, Prentice RL. Comparison of three-day butoconazole treatment with seven-day miconazole treatment for vulvovaginal candidiasis. J Reprod Med. 1989 Jul;34(7):479-83. PMID: 2671362.


18: Anik ST, Sukumar L. Extreme vertexes design in formulation development: solubility of butoconazole nitrate in a multicomponent system. J Pharm Sci. 1981 Aug;70(8):897-900. doi: 10.1002/jps.2600700816. PMID: 7310658.


19: Wong AB. Effect of butoconazole nitrate cream and wax insert on the barrier property of contraceptive devices. Am J Obstet Gynecol. 1988 Apr;158(4):1011-3. doi: 10.1016/0002-9378(88)90117-2. PMID: 3364488.


20: Valentin A, Bernard C, Mallié M, Huerre M, Bastide JM. Control of Candida albicans vaginitis in mice by short-duration butoconazole treatment in situ. Mycoses. 1993 Nov-Dec;36(11-12):379-84. doi: 10.1111/j.1439-0507.1993.tb00726.x. PMID: 7935569.