JNJ-42165279
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 522477

CAS#: 1346528-50-4 (free base); 1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)

Description: JNJ-42165279 is a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoylethanolamide (OEA), and palmitoyl ethanolamide (PEA). JNJ-42165279 was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. JNJ-42165279 is currently under clinical trials.


Chemical Structure

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JNJ-42165279
CAS# 1346528-50-4 (free base); 1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)

Theoretical Analysis

MedKoo Cat#: 522477
Name: JNJ-42165279
CAS#: 1346528-50-4 (free base); 1346528-52-6 (mono HCl salt); 1346528-51-5 (2HCl salt)
Chemical Formula: C18H17ClF2N4O3
Exact Mass: 410.09572
Molecular Weight: 410.81
Elemental Analysis: C, 52.63; H, 4.17; Cl, 8.63; F, 9.25; N, 13.64; O, 11.68

Price and Availability

Size Price Availability Quantity
100.0mg USD 1350.0 2 Weeks
200.0mg USD 2250.0 2 Weeks
500.0mg USD 2950.0 2 Weeks
1.0g USD 4950.0 2 Weeks
2.0g USD 7950.0 2 Weeks
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Synonym: JNJ-42165279; JNJ 42165279; JNJ42165279.

IUPAC/Chemical Name: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide

InChi Key: YWGYNGCRVZLMCS-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)

SMILES Code: O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 410.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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John M. Keith,* William M. Jones, Mark Tichenor, Jing Liu, Mark Seierstad, James A. Palmer, Michael Webb, Mark Karbarz, Brian P. Scott, Sandy J. Wilson, Lin Luo, Michelle L. Wennerholm, Leon Chang, Michele Rizzolio, Raymond Rynberg, Sandra R. Chaplan, and J. Guy Breitenbucher. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279, ACS Med. Chem. Lett. Articles ASAP (As Soon As Publishable), Publication Date (Web): November 2, 2015 (Letter), DOI: 10.1021/acsmedchemlett.5b00353