C646
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407171

CAS#: 328968-36-1

Description: C646 is a potent histone acetyltransferase p300 inhibitor. C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cells. C646 radiosensitizes lung cancer cells by enhancing mitotic catastrophe. C646 reverses epithelial to mesenchymal transition of human peritoneal mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Note: this molecule exists as a mixture of cis- and trans- isomers.


Price and Availability

Size
Price

5mg
USD 120
500mg
USD 1450
5g
USD 5250
Size
Price

100mg
USD 350
1g
USD 1950
Size
Price

200mg
USD 650
2g
USD 3250

C646, purity > 98%, purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 10mg may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407171
Name: C646
CAS#: 328968-36-1
Chemical Formula: C24H19N3O6
Exact Mass: 445.12739
Molecular Weight: 445.43
Elemental Analysis: C, 64.72; H, 4.30; N, 9.43; O, 21.55


Synonym: C646; C-646; C 646.

IUPAC/Chemical Name: (E)-4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid

InChi Key: HEKJYZZSCQBJGB-XDHOZWIPSA-N

InChi Code: InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12+

SMILES Code: O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1


Technical Data

Appearance:
Orange to red solid powder

Purity:
>98% (Note: this molecule exists as a mixture of cis- and trans- isomers)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Yang Y, Liu K, Liang Y, Chen Y, Chen Y, Gong Y. Histone acetyltransferase
inhibitor C646 reverses epithelial to mesenchymal transition of human peritoneal
mesothelial cells via blocking TGF-β1/Smad3 signaling pathway in vitro. Int J
Clin Exp Pathol. 2015 Mar 1;8(3):2746-54. eCollection 2015. PubMed PMID:
26045780; PubMed Central PMCID: PMC4440089.

2: Oike T, Komachi M, Ogiwara H, Amornwichet N, Saitoh Y, Torikai K, Kubo N,
Nakano T, Kohno T. C646, a selective small molecule inhibitor of histone
acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic
catastrophe. Radiother Oncol. 2014 May;111(2):222-7. doi:
10.1016/j.radonc.2014.03.015. Epub 2014 Apr 17. PubMed PMID: 24746574.

3: Gao XN, Lin J, Ning QY, Gao L, Yao YS, Zhou JH, Li YH, Wang LL, Yu L. A
histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and
apoptosis selectively in AML1-ETO-positive AML cells. PLoS One. 2013;8(2):e55481.
doi: 10.1371/journal.pone.0055481. Epub 2013 Feb 4. PubMed PMID: 23390536; PubMed
Central PMCID: PMC3563640.