WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 522395
CAS#: 1229652-21-4
Description: HA130 is a potent and selective autotaxin (ATX) inhibitor (IC50 = 28 nM). HA130 slows T cell migration across lymph node HEVs in vivo. Ex vivo, HA130 blunts the TEM-promoting activity of ATX, paralleling its in vivo effects.
MedKoo Cat#: 522395
Name: HA130
CAS#: 1229652-21-4
Chemical Formula: C24H19BFNO5S
Exact Mass: 463.1061
Molecular Weight: 463.29
Elemental Analysis: C, 62.22; H, 4.13; B, 2.33; F, 4.10; N, 3.02; O, 17.27; S, 6.92
Synonym: HA130; HA-130; HA 130.
IUPAC/Chemical Name: (Z)-(3-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
InChi Key: VTNKMYWFWQTEHE-XKZIYDEJSA-N
InChi Code: InChI=1S/C24H19BFNO5S/c26-20-8-4-17(5-9-20)14-27-23(28)22(33-24(27)29)13-16-6-10-21(11-7-16)32-15-18-2-1-3-19(12-18)25(30)31/h1-13,30-31H,14-15H2/b22-13-
SMILES Code: OB(C1=CC=CC(COC2=CC=C(/C=C(SC(N3CC4=CC=C(F)C=C4)=O)/C3=O)C=C2)=C1)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 463.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Park SJ, Lee KP, Kang S, Chung HY, Bae YS, Okajima F, Im DS.
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer
cells. Cell Signal. 2013 Nov;25(11):2147-54. doi: 10.1016/j.cellsig.2013.07.001.
Epub 2013 Jul 6. PubMed PMID: 23838008.
2: Lai SL, Yao WL, Tsao KC, Houben AJ, Albers HM, Ovaa H, Moolenaar WH, Lee SJ.
Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right
asymmetry in zebrafish. Development. 2012 Dec 1;139(23):4439-48. doi:
10.1242/dev.081745. Epub 2012 Oct 24. PubMed PMID: 23095890.
3: Zhang Y, Chen YC, Krummel MF, Rosen SD. Autotaxin through lysophosphatidic
acid stimulates polarization, motility, and transendothelial migration of naive T
cells. J Immunol. 2012 Oct 15;189(8):3914-24. doi: 10.4049/jimmunol.1201604. Epub
2012 Sep 7. PubMed PMID: 22962684; PubMed Central PMCID: PMC3509168.
