WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407150
Description: ML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. ML-277 has IC50 = 15 nM; Ki = 37 nM. ML-277 shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively).
MedKoo Cat#: 407150
Name: ML-277 (Chk2 Inhibitor II)
Chemical Formula: C20H14ClN3O2
Exact Mass: 363.07745
Molecular Weight: 363.8
Elemental Analysis: C, 66.03; H, 3.88; Cl, 9.74; N, 11.55; O, 8.80
Synonym: ML-277; ML 277; ML277; Chk2 Inhibitor II.
IUPAC/Chemical Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
InChi Key: UXGJAOIJSROTTN-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
SMILES Code: O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N