ML-277 (Chk2 Inhibitor II)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407150

CAS#: 516480-79-8

Description: ML-277, also known as Chk2 Inhibitor II, is a Chk2 (checkpoint kinase 2) inhibitor. BML-277 protects T cells from apoptosis by controlling the response of p53 to radiation-induced DNA breaks. ML-277 has IC50 = 15 nM; Ki = 37 nM. ML-277 shows 1000-fold greater selectivity for the Chk2 serine/threonine kinase than for the Cdk1/B and CK1 kinases (for which IC50 = 12 μM and 17 μM, respectively).


Price and Availability

Size
Price

10mg
USD 90
100mg
USD 450
1g
USD 1950
Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3450
Size
Price

50mg
USD 250
500mg
USD 1250
5g
USD 5950

ML-277 (Chk2 Inhibitor II), purity > 98%, is in stock. The same day shipping out after order is received. Note: the estimated shipping out time for order > 1g may be 2 weeks.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407150
Name: ML-277 (Chk2 Inhibitor II)
CAS#: 516480-79-8
Chemical Formula: C20H14ClN3O2
Exact Mass: 363.07745
Molecular Weight: 363.8
Elemental Analysis: C, 66.03; H, 3.88; Cl, 9.74; N, 11.55; O, 8.80


Synonym: ML-277; ML 277; ML277; Chk2 Inhibitor II.

IUPAC/Chemical Name: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

InChi Key: UXGJAOIJSROTTN-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)

SMILES Code: O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N


Technical Data

Appearance:
White to off-white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490