VWN38241 | BPD-A-1,4-diene | CAS#94238-24-1 | verteporfin | photosensitizer | PDT drug

VWN38241
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 610223

CAS#: 94238-24-1

Description: VWN38241, also known as BPD-A-1,4-diene , and benzoporphyrin derivative Ring A -1,4-diene, is an important precursor for making PDT drug verteporfin. Verteporfin (trade name Visudyne), a benzoporphyrin derivative, is a medication used as a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as the wet form of macular degeneration. This product has no formal name at the moment. For the convenience of communication, a temporary code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

VWN38241

CAS# 94238-24-1

Instruction

Theoretical Analysis

MedKoo Cat#: 610223
Name: VWN38241
CAS#: 94238-24-1
Chemical Formula: C42H44N4O8
Exact Mass: 732.32
Molecular Weight: 732.830
Elemental Analysis: C, 68.84; H, 6.05; N, 7.65; O, 17.47

Price and Availability

Size	Price	Availability
5mg	USD 350	Ready to ship
10mg	USD 650	Ready to ship
25mg	USD 1450	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: benzoporphyrin derivative Ring A -1,4-diene; BPD-A-1,4-diene; VWN38241; VWN-38241; VWN 38241;

IUPAC/Chemical Name: 23H,25H-Benzo[b]porphine-9,13-dipropanoic acid,18-ethenyl-2,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19- tetramethyl-, dimethyl ester

InChi Key: VTMVQLSZTQAYOV-WKGWVRGVSA-N

InChi Code: InChI=1S/C42H44N4O8/c1-10-24-21(2)30-18-35-28-14-11-27(40(49)53-8)39(41(50)54-9)42(28,5)36(46-35)20-31-23(4)26(13-16-38(48)52-7)34(45-31)19-33-25(12-15-37(47)51-6)22(3)29(44-33)17-32(24)43-30/h10,14,17-20,43,45H,1,11-13,15-16H2,2-9H3/b29-17-,30-18-,31-20-,32-17-,33-19-,34-19-,35-18-,36-20-

SMILES Code: COC(CCC1=C(C(/C=C2C(C=C)=C(/C(N/2)=C/C3=N/C(C4(C(C(OC)=O)=C(CC=C43)C(OC)=O)C)=C\C5=C6C)C)=N/C1=C\C(N5)=C6CCC(OC)=O)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 689 nm in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. Verteporfin is also used off-label for the treatment of central serous retinopathy.

Certificate of Analysis:

View CoA: current batch, Lot#CQQ90923

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 732.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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