BYK204165

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 407143

CAS#: 1104546-89-5

Description: BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). BYK204165 was found to be 100-fold more selective for PARP-1. BYK204165 might be novel and valuable tool for investigating PARP-1-mediated effects.


Price and Availability

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10mg
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100mg
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1g
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25mg
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200mg
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2g
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50mg
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500mg
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5g
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BYK204165, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 407143
Name: BYK204165
CAS#: 1104546-89-5
Chemical Formula: C15H12N2O2
Exact Mass: 252.08988
Molecular Weight: 252.27
Elemental Analysis: C, 71.42; H, 4.79; N, 11.10; O, 12.68


Synonym: BYK204165; BYK-204165; BYK 204165; RT-017290; RT017290; RT 017290.

IUPAC/Chemical Name: (4Z)-4-[(1-methylpyrrol-2-yl)methylidene]isoquinoline-1,3-dione

InChi Key: BTYSIDSTHDDAJW-LCYFTJDESA-N

InChi Code: InChI=1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-

SMILES Code: O=C1NC(/C(C2=C1C=CC=C2)=C\C3=CC=CN3C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
293490


References

1: Eltze T, Boer R, Wagner T, Weinbrenner S, McDonald MC, Thiemermann C, Bürkle A, Klein T. Imidazoquinolinone, imidazopyridine, and isoquinolindione derivatives as novel and potent inhibitors of the poly(ADP-ribose) polymerase (PARP): a comparison with standard PARP inhibitors. Mol Pharmacol. 2008 Dec;74(6):1587-98. doi: 10.1124/mol.108.048751. Epub 2008 Sep 22. PubMed PMID: 18809672.