Ganoderic Acid A
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MedKoo CAT#: 600138

CAS#: 81907-62-2

Description: Ganoderic acids are a class of closely related triterpenoids (derivatives from lanosterol) found in Ganoderma mushrooms. For thousands of years, the fruiting bodies of Ganoderma fungi have been used in traditional medicines in East Asia. Consequently, there have been efforts to identify the chemical constituents that may be responsible for the putative pharmacological effects. There are dozens of ganoderic acids that have been isolated and characterized, of which ganoderic acid A and ganoderic acid B are the most well characterized. Some ganoderic acids have been found to possess biological activities including hepatoprotection, anti-tumor effects, and 5-alpha reductase inhibition. (Source: http://en.wikipedia.org/wiki/Ganoderic_acid).


Chemical Structure

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Ganoderic Acid A
CAS# 81907-62-2

Theoretical Analysis

MedKoo Cat#: 600138
Name: Ganoderic Acid A
CAS#: 81907-62-2
Chemical Formula: C30H44O7
Exact Mass: 516.3087
Molecular Weight: 516.67
Elemental Analysis: C, 69.74; H, 8.58; O, 21.68

Price and Availability

Size Price Availability Quantity
100.0mg USD 1950.0 2 Weeks
200.0mg USD 2950.0 2 Weeks
500.0mg USD 3950.0 2 Weeks
1.0g USD 4250.0 2 Weeks
2.0g USD 6950.0 2 Weeks
5.0g USD 11450.0 2 Weeks
10.0g USD 21650.0 2 Weeks
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Synonym:

IUPAC/Chemical Name: (25R)-7β,15α-Dihydroxy-3,11,23-trioxo-5α-lanost-8-en-26-oic acid

InChi Key: DYOKDAQBNHPJFD-JNTBEZBXSA-N

InChi Code: InChI=1S/C30H44O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,23,32,35H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,23+,28+,29-,30+/m1/s1

SMILES Code: CC1(C)C(CC[C@]2(C)C3=C([C@@]4([C@@H](O)C[C@@H]([C@]4(CC3=O)C)[C@H](C)CC(C[C@@H](C)C(O)=O)=O)C)[C@@H](O)C[C@@]12[H])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Biological target: Ganoderic acid A can inhibit of the JAK-STAT3 signaling pathway.
In vitro activity: The present data indicated that pretreatment with GAA (ganoderic acid A) notably suppressed the mRNA expression of TLR2, TLR4, NLRP3, and caspase-1 induced by H2O2 (Figure 6(a)) in NP (nuceus pulposus) cells. Meanwhile, western blot analysis showed that GAA could significantly inhibit the expressions of these proteins (Figure 6(b)). Thus, TLR4/NLRP3 signaling pathway activation induced by H2O2 could be attenuated by GAA. Reference: Bioengineered. 2022 May;13(5):11684-11693. https://pubmed.ncbi.nlm.nih.gov/35506157/
In vivo activity: Compared to thinning, rupture, and basal layer congestion of gastric mucosa in the gastric and duodenal tissues of the FD (functional dyspepsia) group, the tissues in the GAA (ganoderic acid A) and Dom (domperidone) groups revealed intact gastric structure (Figure 2(a)). In addition, epithelial cell swelling, focal necrosis, exfoliation, and massive inflammatory cell infiltration were seen in the duodenal tissue sections of the FD group. Upon treatment with GAA or Dom, however, these symptoms almost disappeared and only mild hyperemia and inflammatory cell infiltration remained with intact duodenal mucosa (Figure 2(b)). Collectively, GAA could significantly alleviate the gastric and duodenal tissue injury in FD rats. Reference: Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. https://pubmed.ncbi.nlm.nih.gov/35685728/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.0 9.68
DMSO 54.5 105.48
Ethanol 51.5 99.68

Preparing Stock Solutions

The following data is based on the product molecular weight 516.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Wang D, Cai X, Xu F, Kang H, Li Y, Feng R. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 May;13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. PMID: 35506157; PMCID: PMC9275919. 2. Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031-1041. doi: 10.17219/acem/137914. PMID: 34329545. 3. Yang W, Liu R, Zhou L, Chen X, Hu Y. Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia. Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. doi: 10.1155/2022/2298665. PMID: 35685728; PMCID: PMC9173975. 4. Zhu J, Ding J, Li S, Jin J. Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. Exp Ther Med. 2022 Apr;23(4):308. doi: 10.3892/etm.2022.11237. Epub 2022 Feb 24. PMID: 35340879; PMCID: PMC8931630.
In vitro protocol: 1. Wang D, Cai X, Xu F, Kang H, Li Y, Feng R. Ganoderic Acid A alleviates the degeneration of intervertebral disc via suppressing the activation of TLR4/NLRP3 signaling pathway. Bioengineered. 2022 May;13(5):11684-11693. doi: 10.1080/21655979.2022.2070996. PMID: 35506157; PMCID: PMC9275919. 2. Wang T, Lu H. Ganoderic acid A inhibits ox-LDL-induced THP-1-derived macrophage inflammation and lipid deposition via Notch1/PPARγ/CD36 signaling. Adv Clin Exp Med. 2021 Oct;30(10):1031-1041. doi: 10.17219/acem/137914. PMID: 34329545.
In vivo protocol: 1. Yang W, Liu R, Zhou L, Chen X, Hu Y. Effects of Ganoderic Acid A on Gastrointestinal Motility and Brain-Gut Peptide in Rats with Functional Dyspepsia. Evid Based Complement Alternat Med. 2022 May 31;2022:2298665. doi: 10.1155/2022/2298665. PMID: 35685728; PMCID: PMC9173975. 2. Zhu J, Ding J, Li S, Jin J. Ganoderic acid A ameliorates non-alcoholic streatohepatitis (NASH) induced by high-fat high-cholesterol diet in mice. Exp Ther Med. 2022 Apr;23(4):308. doi: 10.3892/etm.2022.11237. Epub 2022 Feb 24. PMID: 35340879; PMCID: PMC8931630.

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1: Yajima Y, Miyazaki M, Okita N, Hoshino T. Production of Ginkgo leaf-shaped basidiocarps of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes), containing high levels of α- and β-D-glucan and ganoderic acid A. Int J Med Mushrooms. 2013;15(2):175-82. PubMed PMID: 23557369.