WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 600115
Description: Baicalin is a flavone, a type of flavonoid. It is found in several species in the genus Scutellaria, including Scutellaria lateriflora (blue skullcap). There are 10 mg/g baicalin in Scutellaria galericulata (common skullcap) leaves. Baicalin is the glucuronide of baicalein. It is a component of Chinese medicinal herb Huang-chin (Scutellaria baicalensis) and one of the chemical ingredients of Sho-Saiko-To, an herbal supplement. Baicalin is a known prolyl endopeptidase inhibitor, induces apoptosis in pancreatic cancer cells, and affects the GABA receptors.
MedKoo Cat#: 600115
Chemical Formula: C21H18O11
Exact Mass: 446.08491
Molecular Weight: 446.36
Elemental Analysis: C, 56.51; H, 4.06; O, 39.43p
IUPAC/Chemical Name: (2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenyl-chromen-7-yl)oxy-3,4,5-trihydroxy-tetrahydropyran-2-carboxylic acid
InChi Key: IKIIZLYTISPENI-ZFORQUDYSA-N
InChi Code: InChI=1S/C21H18O11/c22-9-6-10(8-4-2-1-3-5-8)30-11-7-12(14(23)15(24)13(9)11)31-21-18(27)16(25)17(26)19(32-21)20(28)29/h1-7,16-19,21,23-27H,(H,28,29)/t16-,17-,18+,19-,21+/m0/s1
SMILES Code: O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC3=C(C(O)=C2O)C(C=C(C4=CC=CC=C4)O3)=O)O1)O
1: Chai YS, Lei F, Xing DM, Ding Y, Du LJ. [Effect of baicalin on pattern recognition receptor TLR2/4-NOD2 and its significance of druggability]. Zhongguo Zhong Yao Za Zhi. 2013 Aug;38(16):2639-44. Review. Chinese. PubMed PMID: 24228579.
2: Sahebkar A. Baicalin as a potentially promising drug for the management of sulfur mustard induced cutaneous complications: a review of molecular mechanisms. Cutan Ocul Toxicol. 2012 Sep;31(3):226-34. doi: 10.3109/15569527.2011.633950. Epub 2011 Nov 22. Review. PubMed PMID: 22107027.
3: Srinivas NR. Baicalin, an emerging multi-therapeutic agent: pharmacodynamics, pharmacokinetics, and considerations from drug development perspectives. Xenobiotica. 2010 May;40(5):357-67. doi: 10.3109/00498251003663724. Review. PubMed PMID: 20230189.
4: Li-Weber M. New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treat Rev. 2009 Feb;35(1):57-68. doi: 10.1016/j.ctrv.2008.09.005. Epub 2008 Nov 11. Review. PubMed PMID: 19004559.
5: Zhu Y. [The study on baicalin in China]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Sep;13(9):567-9. Review. Chinese. PubMed PMID: 8111218.