NSI-189
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510270

CAS#: 1270138-40-3

Description: NSI-189 is a nootropic and neurogenic research chemica. NSI-189 has been shown to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.


Chemical Structure

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NSI-189
CAS# 1270138-40-3

Theoretical Analysis

MedKoo Cat#: 510270
Name: NSI-189
CAS#: 1270138-40-3
Chemical Formula: C22H30N4O
Exact Mass: 366.24196
Molecular Weight: 366.4998
Elemental Analysis: C, 72.10; H, 8.25; N, 15.29; O, 4.37

Price and Availability

Size Price Availability Quantity
100.0mg USD 450.0 2 Weeks
200.0mg USD 750.0 2 Weeks
500.0mg USD 1550.0 2 Weeks
1.0g USD 2450.0 2 Weeks
2.0g USD 3850.0 2 Weeks
5.0g USD 5250.0 2 Weeks
Bulk inquiry

Synonym: NSI-189; NSI 189; NSI189.

IUPAC/Chemical Name: (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone

InChi Key: DYTOQURYRYYNOR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)

SMILES Code: O=C(N1CCN(CC2=CC=CC=C2)CC1)C3=CC=CN=C3NCCC(C)C

Appearance: white to off-white solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 366.4998 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1372-80. doi:
10.1038/mp.2015.178. PubMed PMID: 26643541; PubMed Central PMCID: PMC5030464.

2: Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM,
Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys
G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled,
multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in
depressed patients. Mol Psychiatry. 2016 Oct;21(10):1483-4. doi:
10.1038/mp.2016.140. PubMed PMID: 27528461; PubMed Central PMCID: PMC5030463

NSI-189

100.0mg / USD 450.0


Additional Information