BX912
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 500408

CAS#: 702674-56-4

Description: BX912 is a selective potent PDK1 inhibitor with IC50 of 12 nM. BX912 blocks PDK1/Akt signaling in tumor cells and suppresses the anchorage-dependent growth of a variety of tumor cell lines (such as PC-3 cells) in culture or induces apoptosis.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 150 2 Weeks
10mg USD 210 2 Weeks
25mg USD 350 2 Weeks
50mg USD 550 2 Weeks
100mg USD 850 2 Weeks
200mg USD 1550 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-07-10. Prices are subject to change without notice.

BX-912, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 500408
Name: BX912
CAS#: 702674-56-4
Chemical Formula: C20H23BrN8O
Exact Mass: 470.11782
Molecular Weight: 471.35
Elemental Analysis: C, 50.96; H, 4.92; Br, 16.95; N, 23.77; O, 3.39


Synonym: BX912; BX 912; BX912.

IUPAC/Chemical Name: N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide

InChi Key: DMMILYKXNCVKOJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23BrN8O/c21-17-12-24-19(28-18(17)23-7-6-16-11-22-13-25-16)26-14-4-3-5-15(10-14)27-20(30)29-8-1-2-9-29/h3-5,10-13H,1-2,6-9H2,(H,22,25)(H,27,30)(H2,23,24,26,28)

SMILES Code: O=C(N1CCCC1)NC2=CC=CC(NC3=NC=C(Br)C(NCCC4=CNC=N4)=N3)=C2


Technical Data

Appearance:
White solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

  
  
 
 


References

1: Mashukova A, Forteza R, Wald FA, Salas PJ. PDK1 in apical signaling endosomes  participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia. Mol Biol Cell. 2012 May;23(9):1664-74. Epub 2012 Mar 7. PubMed PMID: 22398726; PubMed Central PMCID: PMC3338434.