WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 314241
CAS#: 163521-08-2 (HCl)
Description: Vilazodone is a serotonergic antidepressant. Vilazodone was approved by the FDA for use in the United States to treat major depressive disorder in 2011. The mechanism of the antidepressant effect of vilazodone is not fully understood but is thought to be related to its enhancement of serotonergic activity in the CNS through selective inhibition of serotonin reuptake. Vilazodone is also a partial agonist at serotonergic 5-HT1A receptors; however, the net result of this action on serotonergic transmission and its role in vilazodone's antidepressant effect are unknown.
MedKoo Cat#: 314241
Name: Vilazodone hydrochloride
CAS#: 163521-08-2 (HCl)
Chemical Formula: C26H28ClN5O2
Exact Mass:
Molecular Weight: 477.99
Elemental Analysis: C, 65.33; H, 5.90; Cl, 7.42; N, 14.65; O, 6.69
Related CAS #: 163521-08-2 (HCl) 163521-12-8 (free)
Synonym: EMB-68843; EMB68843; EMB68843; Vilazodone hydrochloride; Viibryd
IUPAC/Chemical Name: 5-(4-[4-(5-Cyano-1H-indol-3-yl)butyl]piperazin-1-yl)benzofuran-2-carboxamide, hydrochloride
InChi Key: RPZBRGFNBNQSOP-UHFFFAOYSA-N
InChi Code: InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H
SMILES Code: O=C(C1=CC2=CC(N3CCN(CCCCC4=CNC5=C4C=C(C#N)C=C5)CC3)=CC=C2O1)N.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO.
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 477.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Guay DR. Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorder. Consult Pharm. 2012 Dec;27(12):857-67. doi: 10.4140/TCP.n.2012.857. Review. PubMed PMID: 23229074.
2: Hussar DA, Samuel J. Vilazodone hydrochloride, linagliptin, and alcaftadine. J Am Pharm Assoc (2003). 2011 Jul-Aug;51(4):557-9. doi: 10.1331/JAPhA.2011.11534. PubMed PMID: 21752782.
Related CAS#
163521-08-2 (HCl); 163521-12-8 (free base).
