WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 314238

CAS#: 209860-87-7

Description: Tafluprost, also known as MK2452 and AFP-168, is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure by increasing the outflow of aqueous fluid from the eyes.

Chemical Structure

CAS# 209860-87-7

Theoretical Analysis

MedKoo Cat#: 314238
Name: Tafluprost
CAS#: 209860-87-7
Chemical Formula: C25H34F2O5
Exact Mass: 452.24
Molecular Weight: 452.530
Elemental Analysis: C, 66.35; H, 7.57; F, 8.40; O, 17.68

Price and Availability

Size Price Availability Quantity
10mg USD 150 2 Weeks
25mg USD 250
50mg USD 450
100mg USD 750
200mg USD 1250
500mg USD 1950
1g USD 2950
2g USD 3850
5g USD 6450
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Synonym: AFP-168, AFP-168, AFP-168, MK-2452, MK2452, MK 2452, Saflutan, Taflotan, Tapros, Zioptan

IUPAC/Chemical Name: isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate


InChi Code: InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1

SMILES Code: O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](/C=C/C(F)(F)COC2=CC=CC=C2)[C@H](O)C[C@@H]1O

Appearance: White solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO.

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 452.530000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Niwano Y, Iwasawa A, Ayaki M. Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analog. Ophthalmol Eye Dis. 2014 Feb 13;6:5-12. doi: 10.4137/OED.S12445. eCollection 2014. Review. PubMed PMID: 24558301; PubMed Central PMCID: PMC3928056. 2: Duh D, Tanret I. [Tafluprost (Saflutan) ophthalmic use]. J Pharm Belg. 2013 Jun;(2):41-2. Review. French. PubMed PMID: 23798185. 3: Swymer C, Neville MW. Tafluprost: the first preservative-free prostaglandin to treat open-angle glaucoma and ocular hypertension. Ann Pharmacother. 2012 Nov;46(11):1506-10. doi: 10.1345/aph.1R229. Epub 2012 Oct 23. Review. PubMed PMID: 23092867. 4: Papadia M, Bagnis A, Scotto R, Traverso CE. Tafluprost for glaucoma. Expert Opin Pharmacother. 2011 Oct;12(15):2393-401. doi: 10.1517/14656566.2011.606810. Review. PubMed PMID: 21916788. 5: Pantcheva MB, Seibold LK, Awadallah NS, Kahook MY. Tafluprost: a novel prostaglandin analog for treatment of glaucoma. Adv Ther. 2011 Sep;28(9):707-15. doi: 10.1007/s12325-011-0055-8. Epub 2011 Aug 18. Review. PubMed PMID: 21858491.