WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 405250
Description: WZ811 is a C-X-C chemokine receptor type 4 (CXCR4) antagonist. WZ811 shows subnanomolar potency (EC50 = 0.3 nM) in an affinity binding assay. In addition, when subjected to in vitro functional evaluation, WZ811 efficiently inhibits CXCR4/stromal cell-derived factor-1 (SDF-1)-mediated modulation of cyclic adenosine monophophate (cAMP) levels (EC50 = 1.2 nM) and SDF-1 induced Matrigel invasion (EC50 = 5.2 nM). The chemical structure of WZ811 is very similar to that of MSX-122.
MedKoo Cat#: 405250
Chemical Formula: C18H18N4
Exact Mass: 290.15315
Molecular Weight: 290.36
Elemental Analysis: C, 74.46; H, 6.25; N, 19.30
Synonym: WZ811; WZ-811; WZ 811.
IUPAC/Chemical Name: N,N'-(1,4-phenylenebis(methylene))bis(pyridin-2-amine)
InChi Key: KBVFRXIGQQRMEF-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
SMILES Code: C1(CNC2=NC=CC=C2)=CC=C(CNC3=NC=CC=C3)C=C1
Appearance: White solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 290.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kawatkar SP, Yan M, Gevariya H, Lim MY, Eisold S, Zhu X, Huang Z, An J. Computational analysis of the structural mechanism of inhibition of chemokine receptor CXCR4 by small molecule antagonists. Exp Biol Med (Maywood). 2011 Jul 1;236(7):844-50. doi: 10.1258/ebm.2011.010345. Epub 2011 Jun 22. PubMed PMID: 21697335.
55778-02-4 (WZ811 free base);
898190-81-3 (WZ811-2HCl salt);