PD-169316
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 510236

CAS#: 152121-53-4

Description: PD-169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM. PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 750
2g
USD 3850
Size
Price

50mg
USD 250
500mg
USD 1450
5g
USD 6450
Size
Price

100mg
USD 450
1g
USD 2450

PD169316, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 510236
Name: PD-169316
CAS#: 152121-53-4
Chemical Formula: C20H13FN4O2
Exact Mass: 360.10225
Molecular Weight: 360.34
Elemental Analysis: C, 66.66; H, 3.64; F, 5.27; N, 15.55; O, 8.88


Synonym: PD-169316; PD 169316; PD169316.

IUPAC/Chemical Name: 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridine

InChi Key: BGIYKDUASORTBB-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)

SMILES Code: O=[N+](C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2)C=C1)[O-]


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


Additional Information

  
  
 
 


References

1: Krishnamoorthy M, Heimburg-Molinaro J, Bargo AM, Nash RJ, Nash RJ. Heparin binding epidermal growth factor-like growth factor and PD169316 prevent apoptosis in mouse embryonic stem cells. J Biochem. 2009 Feb;145(2):177-84. doi: 10.1093/jb/mvn153. Epub 2008 Nov 14. PubMed PMID: 19010935; PubMed Central PMCID: PMC2879129.

2: Fu Y, O'Connor LM, Shepherd TG, Nachtigal MW. The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells. Biochem Biophys Res Commun. 2003 Oct 17;310(2):391-7. PubMed PMID: 14521923.