Mizoribine
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406375

CAS#: 50924-49-7

Description: Mizoribine,Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug. The compound was first observed in Tokyo, Japan, in 1971. It is a natural product, first isolated from the mould Eupenicillium brefeldianum. Mizoribine (MZB) is an imidazole nucleoside that has been used in renal transplantation, and in steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases.


Price and Availability

Size
Price

1g
USD 250
50g
USD 4650
Size
Price

5g
USD 950
100g
USD 7650
Size
Price

10g
USD 1650

Mizoribine, purity > 98%, is in stock. The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 406375
Name: Mizoribine
CAS#: 50924-49-7
Chemical Formula: C9H13N3O6
Exact Mass: 259.08044
Molecular Weight: 259.22
Elemental Analysis: C, 41.70; H, 5.05; N, 16.21; O, 37.03


Synonym: Mizoribine; Bredinin; HE 69; He69; He-69; NSC289637; NSC-289637; NSC 289637.

IUPAC/Chemical Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-hydroxy-1H-imidazole-4-carboxamide

InChi Key: HZQDCMWJEBCWBR-UUOKFMHZSA-N

InChi Code: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

SMILES Code: O=C(C1=C(O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=N1)N


Technical Data

Appearance:
white solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

 MZB exerts its activity through selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division. Thus, MZB has less toxicity than azathioprine, another immunosuppressant used for some of the same diseases. (http://en.wikipedia.org/wiki/Mizoribine) (Last updated: 8/06/2015)
 
 


References

1: Zhang X, Fu S, Han S, Zheng X, Wang L. The argument for the use of mizoribine in renal transplantation: a meta-analysis and systemic review. Transpl Immunol. 2013 Mar;28(2-3):106-11. doi: 10.1016/j.trim.2012.12.003. Epub 2013 Jan 9. Review. PubMed PMID: 23313278.

2: Sawada T. [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 5. Leflunomide and mizoribine]. Nihon Naika Gakkai Zasshi. 2011 Oct 10;100(10):2929-35. Review. Japanese. PubMed PMID: 22175133.

3: Kawasaki Y. Mizoribine: a new approach in the treatment of renal disease. Clin Dev Immunol. 2009;2009:681482. doi: 10.1155/2009/681482. Epub 2009 Dec 13. Review. PubMed PMID: 20052390; PubMed Central PMCID: PMC2801010.

4: Kondo H, Iizuka N. [Mizoribine]. Nihon Rinsho. 2005 May;63 Suppl 5:708-12. Review. Japanese. PubMed PMID: 15954433.

5: Tanaka H, Abe T, Nishimura S, Sakai H, Kimura H, Oki M, Nojima M, Taga M, Matsumoto S, Takahashi H, Imai K. [A case of rheumatoid arthritis/Sjogren's syndrome with acute renal failure due to hyperuricemia associated with mizoribine therapy]. Nihon Rinsho Meneki Gakkai Kaishi. 2004 Jun;27(3):171-6. Review. Japanese. PubMed PMID: 15291254.

6: Tsuzuki K. Role of mizoribine in renal transplantation. Pediatr Int. 2002 Apr;44(2):224-31. Review. PubMed PMID: 11896891.

7: Honda M. Nephrotic syndrome and mizoribine in children. Pediatr Int. 2002 Apr;44(2):210-6. Review. PubMed PMID: 11896889.

8: Takei S. Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Pediatr Int. 2002 Apr;44(2):205-9. Review. PubMed PMID: 11896888.

9: Yokota S. Mizoribine: mode of action and effects in clinical use. Pediatr Int. 2002 Apr;44(2):196-8. Review. PubMed PMID: 11896886.

10: Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575-97. Review. PubMed PMID: 10390602.