WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406315
Description: M410 is a vascular disrupting agent, which showed potent cytotoxic activity toward proliferating tumor cells and exhibited a similar cytotoxicity against multi-drug resistant (MDR) tumor cells. M410 inhibited bovine brain tubulin polymerization in a way similar to that of colchicine. In proliferating human umbilical vein endothelial cells (HUVECs), 20 nM of M410 induced cellular tubulin depolymerization within 4 h, which led to M phase arrest. M410 is a potent microtubule inhibitor that is cytotoxic, angiogenesis inhibiting and vascular targeting.
MedKoo Cat#: 406315
Chemical Formula: C17H17Na2O7P
Molecular Weight: 410.27
Elemental Analysis: C, 49.77; H, 4.18; Na, 11.21; O, 27.30; P, 7.55
Synonym: M410; M-410; M 410.
IUPAC/Chemical Name: sodium (Z)-5-(3,5-dimethoxystyryl)-2-methoxyphenyl phosphate
InChi Key: IITOLTJSTUDQOB-WNCVTPEDSA-L
InChi Code: InChI=1S/C17H19O7P.2Na/c1-21-14-8-13(9-15(11-14)22-2)5-4-12-6-7-16(23-3)17(10-12)24-25(18,19)20;;/h4-11H,1-3H3,(H2,18,19,20);;/q;2*+1/p-2/b5-4-;;
SMILES Code: O=P([O-])([O-])OC1=CC(/C=C\C2=CC(OC)=CC(OC)=C2)=CC=C1OC.[Na+].[Na+]
1: Cai YC, Zou Y, Ye YL, Sun HY, Su QG, Wang ZX, Zeng ZL, Xian LJ. Anti-tumor activity and mechanisms of a novel vascular disrupting agent, (Z)-3,4',5-trimethoxylstilbene-3'-O-phosphate disodium (M410). Invest New Drugs. 2011 Apr;29(2):300-11. doi: 10.1007/s10637-009-9366-x. Epub 2009 Dec 11. PubMed PMID: 20012336.