WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 406301

CAS#: 160141-09-3

Description: L-744832, also known as L-744,832, is a potent Farnesyltransferase inhibitor with potential anticancer activity.

Chemical Structure

CAS# 160141-09-3

Theoretical Analysis

MedKoo Cat#: 406301
Name: L-744832
CAS#: 160141-09-3
Chemical Formula: C26H45N3O6S2
Exact Mass: 559.27498
Molecular Weight: 559.782
Elemental Analysis: C, 55.79; H, 8.10; N, 7.51; O, 17.15; S, 11.46

Price and Availability

Size Price Availability Quantity
1.0mg USD 305.0 2 Weeks
5.0mg USD 475.0 2 Weeks
50.0mg USD 2000.0 2 Weeks
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Synonym: L744832; L 744832; L-744832

IUPAC/Chemical Name: (S)-isopropyl 2-((S)-2-(((2S,3S)-2-(((R)-2-amino-3-mercaptopropyl)amino)-3-methylpentyl)oxy)-3-phenylpropanamido)-4-(methylsulfonyl)butanoate


InChi Code: InChI=1S/C26H45N3O6S2/c1-6-19(4)23(28-15-21(27)17-36)16-34-24(14-20-10-8-7-9-11-20)25(30)29-22(12-13-37(5,32)33)26(31)35-18(2)3/h7-11,18-19,21-24,28,36H,6,12-17,27H2,1-5H3,(H,29,30)/t19-,21+,22-,23+,24-/m0/s1

SMILES Code: O=C(OC(C)C)[C@@H](NC([C@@H](OC[C@@H](NC[C@@H](N)CS)[C@@H](C)CC)CC1=CC=CC=C1)=O)CCS(=O)(C)=O

Appearance: Solid powder

Purity: >98%

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 559.782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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 1: Spindler SR, Li R, Dhahbi JM, Yamakawa A, Mote P, Bodmer R, Ocorr K, Williams
RT, Wang Y, Ablao KP. Statin treatment increases lifespan and improves cardiac
health in Drosophila by decreasing specific protein prenylation. PLoS One.
2012;7(6):e39581. doi: 10.1371/journal.pone.0039581. Epub 2012 Jun 21. PubMed
PMID: 22737247; PubMed Central PMCID: PMC3380867.

2: Murphy LA, Moore T, Nesnow S. Propiconazole-enhanced hepatic cell
proliferation is associated with dysregulation of the cholesterol biosynthesis
pathway leading to activation of Erk1/2 through Ras farnesylation. Toxicol Appl
Pharmacol. 2012 Apr 15;260(2):146-54. doi: 10.1016/j.taap.2012.02.003. Epub 2012
Feb 14. PubMed PMID: 22361350.

Additional Information