WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 406358
CAS#: 623578-11-0
Description: KU-0058684 is a potent PARP and DNA-PK inhibitors.
MedKoo Cat#: 406358
Name: KU-0058684
CAS#: 623578-11-0
Chemical Formula: C19H14FN3O3
Exact Mass: 351.10192
Molecular Weight: 351.33
Elemental Analysis: C, 64.95; H, 4.02; F, 5.41; N, 11.96; O, 13.66
Synonym: KU0058684; KU-0058684; KU 0058684; KU58684; KU 58684; KU-58684
IUPAC/Chemical Name: 1-(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)phenyl)pyrrolidine-2,5-dione
InChi Key: YQSZNYLPVBOGPO-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H14FN3O3/c20-14-6-5-11(10-16(14)23-17(24)7-8-18(23)25)9-15-12-3-1-2-4-13(12)19(26)22-21-15/h1-6,10H,7-9H2,(H,22,26)
SMILES Code: O=C(CC1)N(C2=CC(CC3=NNC(C4=C3C=CC=C4)=O)=CC=C2F)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 351.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Sousa MM, Zub KA, Aas PA, Hanssen-Bauer A, Demirovic A, Sarno A, Tian E, Liabakk NB, Slupphaug G. An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells. PLoS One. 2013;8(2):e55493. doi: 10.1371/journal.pone.0055493. Epub 2013 Feb 6. PubMed PMID: 23405159; PubMed Central PMCID: PMC3566207.
2: Urbin SS, Elvers I, Hinz JM, Helleday T, Thompson LH. Uncoupling of RAD51 focus formation and cell survival after replication fork stalling in RAD51D null CHO cells. Environ Mol Mutagen. 2012 Mar;53(2):114-24. doi: 10.1002/em.21672. Epub 2012 Jan 4. PubMed PMID: 22302683.
