EHT-6706

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 410440

CAS#: 1351592-10-3 (EHT-6706 free base); 1351592-09-0 (EHT-6706-2HCl salt)

Description: EHT-6706 is a novel microtubule-disrupting agent that targets the colchicine-binding site to inhibit tubulin polymerization. At low nM concentrations, EHT 6706 exhibits highly potent antiproliferative activity on more than 60 human tumor cell lines, even those described as being drug resistant. EHT 6706 also shows strong efficacy as a vascular-disrupting agent, since it prevents endothelial cell tube formation and disrupts pre-established vessels, changes the permeability of endothelial cell monolayers and inhibits endothelial cell migration. Genome-wide transcriptomic analysis of EHT 6706 effects on human endothelial cells shows that the antiangiogenic activity elicits gene deregulations of antiangiogenic pathways. These findings indicate that EHT 6706 is a promising tubulin-binding compound with potentially broad clinical antitumor efficacy.

Chemical Structure

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EHT-6706
CAS# 1351592-10-3 (EHT-6706 free base); 1351592-09-0 (EHT-6706-2HCl salt)
Instruction

Theoretical Analysis

MedKoo Cat#: 410440
Name: EHT-6706
CAS#: 1351592-10-3 (EHT-6706 free base); 1351592-09-0 (EHT-6706-2HCl salt)
Chemical Formula: C21H26Cl2N2O4
Exact Mass: 0.00
Molecular Weight: 441.348
Elemental Analysis: C, 57.15; H, 5.94; Cl, 16.07; N, 6.35; O, 14.50

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: EHT6706; EHT 6706; EHT-6706.

IUPAC/Chemical Name: 7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine dihydrochloride

InChi Key: VGHUBZMBLUZIJE-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H24N2O4.2ClH/c1-5-27-17-7-6-15-14(11-23-12-16(15)20(17)22)8-13-9-18(24-2)21(26-4)19(10-13)25-3;;/h6-7,9-12H,5,8,22H2,1-4H3;2*1H

SMILES Code: NC1=C(OCC)C=CC2=C1C=NC=C2CC3=CC(OC)=C(OC)C(OC)=C3.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >5 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:         

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 441.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Belzacq-Casagrande AS, Bachelot F, De Oliveira C, Coutadeur S, Maurier-Mahé F, Throo E, Chauvignac C, Pognante L, Petibon A, Taverne T, Beausoleil E, Leblond B, Pando MP, Désiré L. Vascular disrupting activity and the mechanism of action of EHT 6706, a novel anticancer tubulin polymerization inhibitor. Invest New Drugs.  2012 Aug 10. [Epub ahead of print] PubMed PMID: 22878926.

2: Clémenson C, Chargari C, Désiré L, Casagrande AS, Bourhis J, Deutsch E. Assessment of the novel tubulin-binding agent EHT 6706 in combination with ionizing radiation or chemotherapy. Invest New Drugs. 2012 Dec;30(6):2173-86. doi: 10.1007/s10637-011-9785-3. Epub 2012 Jan 14. PubMed PMID: 22246215.