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MedKoo CAT#: 406243

CAS#: 86030-08-2

Description: BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A’s MT-stimulated ATPase activity, with an IC50 of 1.7–1.9 M . It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A’s MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A’s double functionality within mitosis and assessing for potential therapeutic utilities.

Price and Availability

Size Price Shipping out time Quantity
250mg USD 215 2 Weeks
500mg USD 375 2 Weeks
1g USD 565 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-04-07. Prices are subject to change without notice.

BTB-1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 406243
Name: BTB-1
CAS#: 86030-08-2
Chemical Formula: C12H8ClNO4S
Exact Mass: 296.98626
Molecular Weight: 297.71
Elemental Analysis: C, 48.41; H, 2.71; Cl, 11.91; N, 4.70; O, 21.50; S, 10.77

Synonym: BTB1; BTB 1 ; BTB-1.

IUPAC/Chemical Name: 4-chloro-2-nitro-1-(phenylsulfonyl)benzene


InChi Code: InChI=1S/C12H8ClNO4S/c13-9-6-7-12(11(8-9)14(15)16)19(17,18)10-4-2-1-3-5-10/h1-8H

SMILES Code: O=S(C1=CC=C(Cl)C=C1[N+]([O-])=O)(C2=CC=CC=C2)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO, not in water

Shelf Life:
>5 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

Additional Information



1: Catarinella M, Grüner T, Strittmatter T, Marx A, Mayer TU. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6. doi: 10.1002/anie.200904510. PubMed PMID: 19856362.