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MedKoo CAT#: 203180
CAS#: 90494-79-4 (HCl)
Description: Xaliproden, also known as SR57746, is a drug which acts as a 5HT1A agonist. It has neurotrophic and neuroprotective effects in vitro, and has been proposed for use in the treatment of several neurodegenerative conditions including amyotrophic lateral sclerosis and Alzheimer's disease.
MedKoo Cat#: 203180
Name: Xaliproden HCl
CAS#: 90494-79-4 (HCl)
Chemical Formula: C24H23ClF3N
Exact Mass: 381.17043
Molecular Weight: 417.9
Elemental Analysis: C, 68.98; H, 5.55; Cl, 8.48; F, 13.64; N, 3.35
Related CAS #: 90494-79-4 (HCl) 135354-02-8 (free base)
Synonym: SR57746; SR-57746; SR 57746; SR 57746A; SR-57746A; SR 57746A; Xaliproden HCl; Xaliproden hydrochloride
IUPAC/Chemical Name: 1-[2-(2-naphthyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine hydrochloride
InChi Key: WVHBEIJGAINUBW-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H
SMILES Code: FC(C1=CC(C2=CCN(CCC3=CC=C4C=CC=CC4=C3)CC2)=CC=C1)(F)F.[H]Cl
Xaliproden (codenamed SR57746) is a drug which acts as a 5HT1A agonist It has neurotrophic and neuroprotective effects in vitro, and has been proposed for use in the treatment of several neurodegenerative conditions including amyotrophic lateral sclerosis (ALS) and Alzheimer's disease. Development of xaliproden for these two indications was discontinued in 2007 following analysis of Phase III data. While the drug did show an effect on hippocampal volume (suggesting perhaps a slowing of cell loss), there was insufficient evidence for efficacy in counteracting Alzheimer's related cognitive decline. Similarly while there were some indicators of efficacy in ALS, including a small but clinically noteworthy effect on some functional parameters, the overall benefit did not reach statistical significance when results across several Phase III trials were averaged. Xaliproden remains under investigation for treatment of peripheral neuropathy associated with chemotherapy. see wikepedia.com.
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