WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 205655
Description: TXA127, also known as Angiotensin i (1-7), is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway.
MedKoo Cat#: 205655
Chemical Formula: C41H62N12O11
Exact Mass: 898.4661
Molecular Weight: 899.02
Elemental Analysis: C, 54.78; H, 6.95; N, 18.70; O, 19.58
This product is not in stock, which may be available by custom synthesis.
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Synonym: TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17)
IUPAC/Chemical Name: L-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline
InChi Key: PVHLMTREZMEJCG-GDTLVBQBSA-N
InChi Code: InChI=1S/C41H62N12O11/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56/h10-13,19-22,26-30,32-33,54H,5-9,14-18,42H2,1-4H3,(H,45,47)(H,48,57)(H,49,60)(H,50,61)(H,51,58)(H,52,59)(H,55,56)(H,63,64)(H4,43,44,46)/t22-,26-,27-,28-,29-,30-,32-,33-/m0/s1
SMILES Code: O=C(O)[C@H]1N(C([C@H](CC2=CNC=N2)NC([C@H]([C@@H](C)CC)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)N)=O)=O)=O)=O)=O)=O)CCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >5 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 899.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ábrigo J, Simon F, Cabrera D, Cabello-Verrugio C. Angiotensin-(1-7) Prevents
Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β)
via Mas Receptor Activation. Cell Physiol Biochem. 2016 Nov 14;40(1-2):27-38.
[Epub ahead of print] PubMed PMID: 27842312.
2: Magalhães GS, Rodrigues-Machado MD, Motta-Santos D, Alenina N, Bader M, Santos
RA, Barcelos LS, Campagnole-Santos MJ. CHRONIC ALLERGIC PULMONARY INFLAMMATION IS
AGGRAVATED IN ANGIOTENSIN-(1-7) MAS RECEPTOR KNOCKOUT MICE. Am J Physiol Lung
Cell Mol Physiol. 2016 Nov 4:ajplung.00029.2016. doi: 10.1152/ajplung.00029.2016.
[Epub ahead of print] PubMed PMID: 27815255.
3: Yu L, Yuan K, Phuong HT, Park BM, Kim SH. Angiotensin-(1-5), an active
mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor.
Peptides. 2016 Sep 20;86:33-41. doi: 10.1016/j.peptides.2016.09.009. [Epub ahead
of print] PubMed PMID: 27660028.
4: Brosnihan KB, M Pulgar V, Bharadwaj MS, Neves LA, Yamaleyeva LM. Local
intra-uterine Ang-(1-7) infusion attenuates PGE(2) and 6-keto PGF(1α) in
decidualized uterus of pseudopregnant rats. Reprod Biol Endocrinol. 2016 Oct
18;14(1):68. PubMed PMID: 27756404; PubMed Central PMCID: PMC5070151.
In 2010, TXA127 was granted Orphan Drug designation as a treatment to enhance engraftment in patients receiving a stem cell transplant. TXA127 has also received Orphan Drug designation for the treatment of Myelodysplastic Syndrome (MDS).