MPP dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 126529

CAS#: 911295-24-4 (HCl)

Description: MPP, also known as Methylpiperidino pyrazole, is a highly selective ERα antagonist. MPP is highly selective for ERα compared to ERβ (Kis = 5.6 nM and 2.3 μM, respectively).2 It can inhibit ERα transcriptional activation with an IC50 value of 80 nM.3 It has been used to evaluate the role of ERα in various estrogen-responsive systems, including certain cancers.

Chemical Structure

MPP dihydrochloride
CAS# 911295-24-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 126529
Name: MPP dihydrochloride
CAS#: 911295-24-4 (HCl)
Chemical Formula: C29H33Cl2N3O3
Exact Mass: 541.19
Molecular Weight: 542.501
Elemental Analysis: C, 64.21; H, 6.13; Cl, 13.07; N, 7.75; O, 8.85

Price and Availability

Size Price Availability Quantity
50mg USD 750 2 Weeks
100mg USD 1250 2 Weeks
200mg USD 1950 2 Weeks
500mg USD 3250 2 Weeks
1g USD 4650 2 Weeks
Bulk inquiry

Related CAS #: 289726-02-9 (free base)   911295-24-4 (HCl)    

Synonym: Methylpiperidino pyrazole; MPP dihydrochloride; MPP (dihydrochloride); MPP HCl; MPP 2HCl;

IUPAC/Chemical Name: 4,4'-(4-methyl-5-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-pyrazole-1,3-diyl)diphenol dihydrochloride


InChi Code: InChI=1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 542.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Jung DW, Jeong DH, Lee HS. Stimulation of estrogen receptor-alpha by hydroxyanilide fungicide, fenhexamid promotes lipid accumulation in 3 T3-L1 adipocyte. Pestic Biochem Physiol. 2024 Feb;199:105757. doi: 10.1016/j.pestbp.2023.105757. Epub 2023 Dec 22. PMID: 38458660.

2: Li Z, Zhu C, Yin C, Li H, Liu Y, Li J. Multi-omics reveals the testosterone promotion effect mechanism of Cordyceps Sobolifera on Leydig cells. J Ethnopharmacol. 2024 May 10;325:117817. doi: 10.1016/j.jep.2024.117817. Epub 2024 Feb 3. PMID: 38316217.

3: Li X, Brighton Ndandala C, Zhou Q, Huang C, Li G, Chen H. Molecular cloning of estrogen receptor and its function on vitellogenesis in pompano (Trachinotus ovatus). Gen Comp Endocrinol. 2024 Jan 15;346:114403. doi: 10.1016/j.ygcen.2023.114403. Epub 2023 Nov 2. PMID: 37923147.

4: Xie X, Zhu Y, Cheng H, Li H, Zhang Y, Wang R, Li W, Wu F. BPA exposure enhances the metastatic aggression of ovarian cancer through the ERα/AKT/mTOR/HIF-1α signaling axis. Food Chem Toxicol. 2023 Jun;176:113792. doi: 10.1016/j.fct.2023.113792. Epub 2023 Apr 18. PMID: 37080528.

5: De la Luz-Cuellar YE, Coffeen U, Mercado F, Granados-Soto V. Spinal dopaminergic D1-and D2-like receptors have a sex-dependent effect in an experimental model of fibromyalgia. Eur J Pharmacol. 2023 Jun 5;948:175696. doi: 10.1016/j.ejphar.2023.175696. Epub 2023 Mar 30. PMID: 37003519.

6: Park HJ, Gholam-Zadeh M, Yoon SY, Suh JH, Choi HS. Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice. Antioxidants (Basel). 2021 Apr 17;10(4):619. doi: 10.3390/antiox10040619. PMID: 33920630; PMCID: PMC8073670.

7: Ye L, Huang J, Xiang X, Song S, Huang G, Ruan Y, Wu S. 17β-Estradiol alleviates cardiac aging induced by d-galactose by downregulating the methylation of autophagy-related genes. Steroids. 2021 Jun;170:108829. doi: 10.1016/j.steroids.2021.108829. Epub 2021 Apr 1. PMID: 33811924.

8: Rodríguez-Merchán EC. A Review of Recent Developments in the Molecular Mechanisms of Bone Healing. Int J Mol Sci. 2021 Jan 14;22(2):767. doi: 10.3390/ijms22020767. PMID: 33466612; PMCID: PMC7828700.

9: Hernández-Vega AM, Del Moral-Morales A, Zamora-Sánchez CJ, Piña-Medina AG, González-Arenas A, Camacho-Arroyo I. Estradiol Induces Epithelial to Mesenchymal Transition of Human Glioblastoma Cells. Cells. 2020 Aug 21;9(9):1930. doi: 10.3390/cells9091930. PMID: 32825553; PMCID: PMC7564468.

10: Jehle J, Tiyerili V, Adler S, Groll K, Nickenig G, Becher UM. Atheroprotective effects of 17β-oestradiol are mediated by peroxisome proliferator-activated receptor γ in human coronary artery smooth muscle cells. Arch Med Sci Atheroscler Dis. 2020 Jun 5;5:e118-e126. doi: 10.5114/amsad.2020.96103. PMID: 32665986; PMCID: PMC7339869.

11: Sen A, Iyer J, Boddu S, Kaul A, Kaul R. Estrogen receptor alpha differentially modulates host immunity in the bladder and kidney in response to urinary tract infection. Am J Clin Exp Urol. 2019 Jun 15;7(3):110-122. PMID: 31317051; PMCID: PMC6627544.

12: Arrieta-Cruz I, Librado-Osorio R, Flores A, Mendoza-Garcés L, Chavira R, Cárdenas M, Gutiérrez-Juárez R, Domínguez R, Cruz ME. Estrogen Receptors Alpha and Beta in POA-AHA Region Regulate Asymmetrically Ovulation. Cell Mol Neurobiol. 2019 Nov;39(8):1139-1149. doi: 10.1007/s10571-019-00708-1. Epub 2019 Jun 27. PMID: 31250245.

13: Kiran Kumar H, Yathirajan HS, Manju N, Kalluraya B, Rathore RS, Glidewell C. Conversion of substituted 5-aryloxypyrazolecarbaldehydes into reduced 3,4'-bipyrazoles: synthesis and characterization, and the structures of four precursors and two products, and their supramolecular assembly in zero, one and two dimensions. Acta Crystallogr C Struct Chem. 2019 Jun 1;75(Pt 6):768-776. doi: 10.1107/S2053229619006752. Epub 2019 May 23. PMID: 31166931.

14: Li M, Zeng M, Zhang ZG, Zhang B, Zhang J, Zheng X, Feng W. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd. Evid Based Complement Alternat Med. 2018 Sep 4;2018:2813465. doi: 10.1155/2018/2813465. PMID: 30254685; PMCID: PMC6142764.

15: Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Häcker H. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Sci Signal. 2018 Aug 14;11(543):eaaq1077. doi: 10.1126/scisignal.aaq1077. PMID: 30108181; PMCID: PMC7195875.

16: Xue L, Liu Z, Hu J, Huang J, Wen J, Liu Z. Estrogen-induced expression of tumor necrosis factor-like weak inducer of apoptosis through ERα accelerates the progression of lupus nephritis. Rheumatology (Oxford). 2016 Oct;55(10):1880-8. doi: 10.1093/rheumatology/kew248. Epub 2016 Jun 28. PMID: 27354685.

17: Kumar MM, Davuluri S, Poojar S, Mukherjee G, Bajpai AK, Bafna UD, Devi UK, Kallur PP, Kshitish AK, Jayshree RS. Role of estrogen receptor alpha in human cervical cancer-associated fibroblasts: a transcriptomic study. Tumour Biol. 2016 Apr;37(4):4409-20. doi: 10.1007/s13277-015-4257-6. Epub 2015 Oct 24. PMID: 26499945.

18: Oche B, Chen L, Ma YK, Yang Y, Li CX, Geng X, Qiu LZ, Gao XM, Wang H. Cryptotanshinone and wogonin up-regulate eNOS in vascular endothelial cells via ERα and down-regulate iNOS in LPS stimulated vascular smooth muscle cells via ERβ. Arch Pharm Res. 2016 Feb;39(2):249-258. doi: 10.1007/s12272-015-0671-y. Epub 2015 Oct 20. PMID: 26481132.

19: Rezende BA, Silva GC, Corradi RG, Teles MM, Barbosa-Filho JM, Lemos VS, Cortes SF. Dihydrogoniothalamin, an Endothelium and NO-Dependent Vasodilator Drug Isolated from Aniba panurensis. Planta Med. 2015 Oct;81(15):1375-81. doi: 10.1055/s-0035-1557775. Epub 2015 Aug 7. PMID: 26252830.

20: Wang L, Qiu XM, Gui YY, Xu YP, Gober HJ, Li DJ. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther. 2015 Jul 21;9:3755-66. doi: 10.2147/DDDT.S88512. PMID: 26229438; PMCID: PMC4516212.