MedKoo Biosciences

Koenimbine
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 125212

CAS#: 21087-98-9

Description: Koenimbine is a natural product isolated from Murraya koenigii.

Chemical Structure

Koenimbine

CAS# 21087-98-9

Instruction

Theoretical Analysis

MedKoo Cat#: 125212
Name: Koenimbine
CAS#: 21087-98-9
Chemical Formula: C19H19NO2
Exact Mass: 293.14
Molecular Weight: 293.370
Elemental Analysis: C, 77.79; H, 6.53; N, 4.77; O, 10.91

Price and Availability

Size	Price	Availability
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3650	2 Weeks
2g	USD 5650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: NSC 127152; Koenimbin; Kenimbine

IUPAC/Chemical Name: 8-methoxy-3,3,5-trimethyl-3,11-dihydropyrano[3,2-a]carbazole

InChi Key: OSERHKINMDLESD-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H19NO2/c1-11-9-15-14-10-12(21-4)5-6-16(14)20-17(15)13-7-8-19(2,3)22-18(11)13/h5-10,20H,1-4H3

SMILES Code: CC1=CC2=C(C3=C1OC(C=C3)(C)C)NC4=C2C=C(C=C4)OC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 293.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Astaneh M, Ghafouri-Fard S, Fazeli Z, Taherian-Esfahani Z, Dashti S,
Motevaseli E. Assessment of anti-cancer effects of koenimbine on colon cancer
cells. Hum Antibodies. 2020;28(3):185-190. doi: 10.3233/HAB-200405. PMID:
32116245.

2: Uvarani C, Ramesh P, Ravichandran K, Mohan PS, Ponnuswamy MN. 8-Meth-
oxy-3,3,5-trimethyl-3,11-dihydro-pyrano[3,2-a]carbazole. Acta Crystallogr Sect E
Struct Rep Online. 2010 Jun 5;66(Pt 7):o1581. doi: 10.1107/S160053681002074X.
PMID: 21587821; PMCID: PMC3006796.

3: Hobani YH. The Role of Oxidative Stress in Koenimbine-Induced DNA Damage and
Heat Shock Protein Modulation in HepG2 Cells. Integr Cancer Ther. 2017
Dec;16(4):563-571. doi: 10.1177/1534735416678982. Epub 2016 Nov 22. PMID:
27879375; PMCID: PMC5739142.

4: Nalli Y, Khajuria V, Gupta S, Arora P, Riyaz-Ul-Hassan S, Ahmed Z, Ali A.
Four new carbazole alkaloids from Murraya koenigii that display anti-
inflammatory and anti-microbial activities. Org Biomol Chem. 2016 Mar
28;14(12):3322-32. doi: 10.1039/c6ob00267f. Erratum in: Org Biomol Chem. 2018
Mar 14;16(11):1994. PMID: 26947457.

5: Chatterjee D, Narzish F, Borade P, Singh IP. Simultaneous quantitation of
nine carbazole alkaloids from Murraya koenigii (L.) Spreng by
¹H qNMR spectroscopy. Nat Prod Res. 2023 Jun 16:1-9. doi:
10.1080/14786419.2023.2219819. Epub ahead of print. PMID: 37322993.

6: Pakrashy S, Mandal PK, Dey SK, Choudhury SM, Alasmary FA, Almalki AS, Islam
MA, Dolai M. Design of a Structurally Novel Multipotent Drug Candidate by the
Scaffold Architecture Technique for ACE-II, NSP15, and M^pro Protein
Inhibition: Identification and Isolation of a Natural Product to Prevent the
Severity of Future Variants of Covid 19 and a Colorectal Anticancer Drug. ACS
Omega. 2022 Sep 10;7(37):33408-33422. doi: 10.1021/acsomega.2c04051. PMID:
36157758; PMCID: PMC9494648.

7: Sadwal S, Bharati S, Dar ZA, Kaur S. Chemopreventive potential of
hydroethanolic Murraya koenigii leaves extract against DMBA induced breast
carcinogenesis: In-silico and in-vivo study. J Ethnopharmacol. 2023 Sep 8;319(Pt
1):117124. doi: 10.1016/j.jep.2023.117124. Epub ahead of print. PMID: 37678421.

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