Pemigatinib HCl

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MedKoo CAT#: 206195

CAS#: 1513857-77-6 (HCl)

Description: Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.


Chemical Structure

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Pemigatinib HCl
CAS# 1513857-77-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 206195
Name: Pemigatinib HCl
CAS#: 1513857-77-6 (HCl)
Chemical Formula: C24H28ClF2N5O4
Exact Mass: 523.1798
Molecular Weight: 523.9658
Elemental Analysis: C, 55.02; H, 5.39; Cl, 6.77; F, 7.25; N, 13.37; O, 12.21

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Related CAS #: 1513857-77-6 (free base)   1513857-77-6 (HCl)    

Synonym: INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828. Pemigatinib HCl; Pemigatinib hydrochloride

IUPAC/Chemical Name: 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(morpholin-4-yl)methyl]-1,3,4,7-tetrahydro-2Hpyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one hydrochloride

InChi Key: JAUWPXUYFRLMAN-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27F2N5O4.ClH/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26;/h9-11H,4-8,12-13H2,1-3H3,(H,27,28);1H

SMILES Code: O=C1N(CC)C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(F)C(OC)=CC(OC)=C5F.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 523.9658 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Additional Information