Pemigatinib HCl

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MedKoo CAT#: 206195

CAS#: 1513857-77-6 (HCl)

Description: Pemigatinib, also known as INCB054828, is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) types 1, 2, and 3 (FGFR1/2/3), with potential antineoplastic activity. FGFR inhibitor INCB054828 binds to and inhibits FGFR1/2/3, which may result in the inhibition of FGFR1/2/3-related signal transduction pathways. This inhibits proliferation in FGFR1/2/3-overexpressing tumor cells.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-05-28. Prices are subject to change without notice.

Pemigatinib HCl is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206195
Name: Pemigatinib HCl
CAS#: 1513857-77-6 (HCl)
Chemical Formula: C24H28ClF2N5O4
Exact Mass: 523.1798
Molecular Weight: 523.9658
Elemental Analysis: C, 55.02; H, 5.39; Cl, 6.77; F, 7.25; N, 13.37; O, 12.21


Related CAS #: 1513857-77-6 (free base)   1513857-77-6 (HCl)    

Synonym: INCB054828; INCB-054828; INCB 054828; INCB54828; INCB 54828; INCB-54828. Pemigatinib HCl; Pemigatinib hydrochloride

IUPAC/Chemical Name: 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-[(morpholin-4-yl)methyl]-1,3,4,7-tetrahydro-2Hpyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one hydrochloride

InChi Key: JAUWPXUYFRLMAN-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H27F2N5O4.ClH/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26;/h9-11H,4-8,12-13H2,1-3H3,(H,27,28);1H

SMILES Code: O=C1N(CC)C2=C3C(NC(CN4CCOCC4)=C3)=NC=C2CN1C5=C(F)C(OC)=CC(OC)=C5F.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

  
 
 
 


References