MedKoo Biosciences

Alnustone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 124030

CAS#: 33457-62-4

Description: Alnustone is a naturally occurring compound found in the rhizomes of Curcuma xanthorrhiza. Alnustone exhibits anti-inflammatory, antihepatotoxic and antiemetic activities.

Chemical Structure

Alnustone

CAS# 33457-62-4

Instruction

Theoretical Analysis

MedKoo Cat#: 124030
Name: Alnustone
CAS#: 33457-62-4
Chemical Formula: C19H18O
Exact Mass: 262.14
Molecular Weight: 262.350
Elemental Analysis: C, 86.99; H, 6.92; O, 6.10

Price and Availability

Size	Price	Availability
10mg	USD 350	2 Weeks
25mg	USD 550	2 Weeks
50mg	USD 950	2 Weeks
100mg	USD 1650	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Alnustone; 33457-62-4; (4E,6E)-1,7-diphenylhepta-4,6-dien-3-one; CHEMBL461082; (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one

IUPAC/Chemical Name: (4E,6E)-1,7-diphenylhepta-4,6-dien-3-one

InChi Key: OWMJDOUOHDOUFG-FNCQTZNRSA-N

InChi Code: InChI=1S/C19H18O/c20-19(16-15-18-11-5-2-6-12-18)14-8-7-13-17-9-3-1-4-10-17/h1-14H,15-16H2/b13-7+,14-8+

SMILES Code: O=C(CCc1ccccc1)/C=C/C=C/c1ccccc1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 262.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Wang L, Cheng L, Ma L, Ahmad Farooqi A, Qiao G, Zhang Y, Ye H, Liu M, Huang
J, Yang X, Lin X, Cao S. Alnustone inhibits the growth of hepatocellular
carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis. Phytother Res. 2022
Jan;36(1):525-542. doi: 10.1002/ptr.7337. Epub 2021 Nov 30. PMID: 34847624.

2: Zhang C, Deng Y, Wang X, Shi L, Zhan B, Hou N, Liu S, Bao M, Chi G, Fang T.
Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin
and sortase A. Fitoterapia. 2022 Oct;162:105261. doi:
10.1016/j.fitote.2022.105261. Epub 2022 Aug 6. PMID: 35944753.

3: Song Y, Zhou Y, Yan XT, Bi JB, Qiu X, Bian Y, Wang KF, Zhang Y, Feng XS.
Pharmacokinetics and Tissue Distribution of Alnustone in Rats after Intravenous
Administration by Liquid Chromatography-Mass Spectrometry. Molecules. 2019 Sep
2;24(17):3183. doi: 10.3390/molecules24173183. PMID: 31480657; PMCID:
PMC6749364.

4: Li Z. Comment on: Alnustone inhibits the growth of hepatocellular carcinoma
via reactive oxygen species-mediated PI3K/Akt/mTOR/p70S6K axis. Phytother Res.
2023 Jun;37(6):2215-2216. doi: 10.1002/ptr.7708. Epub 2022 Dec 22. PMID:
36560899.

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