ZM 226600 | CAS#147695-92-9 | KATP channel opener

ZM-226600
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556341

CAS#: 147695-92-9

Description: ZM-226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties. ZM226600 is more active than oxybutynin in reducing bladder overactivity, and it is devoid of vascular side effects observed with pinacidil. Its short duration of action (about 1 h) is probably the main problem to solve, in order to consider this compound a valid alternative to antimuscarinics in the therapy of bladder overactivity.

Chemical Structure

ZM-226600

CAS# 147695-92-9

Instruction

Theoretical Analysis

MedKoo Cat#: 556341
Name: ZM-226600
CAS#: 147695-92-9
Chemical Formula: C16H14F3NO4S
Exact Mass: 373.06
Molecular Weight: 373.346
Elemental Analysis: C, 51.47; H, 3.78; F, 15.27; N, 3.75; O, 17.14; S, 8.59

Price and Availability

Size	Price	Availability
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3850	2 Weeks
2g	USD 5950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ZM-226600; ZM 226600; ZM226600;

IUPAC/Chemical Name: N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide

InChi Key: LJLXQHHFAKVTNP-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14F3NO4S/c1-15(22,16(17,18)19)14(21)20-11-7-9-13(10-8-11)25(23,24)12-5-3-2-4-6-12/h2-10,22H,1H3,(H,20,21)

SMILES Code: O=C(NC1=CC=C(S(=O)(C2=CC=CC=C2)=O)C=C1)C(C)(O)C(F)(F)F

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 373.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Dyhring T, Jansen-Olesen I, Christophersen P, Olesen J. Pharmacological Profiling of KATP Channel Modulators: An Outlook for New Treatment Opportunities for Migraine. Pharmaceuticals (Basel). 2023 Feb 1;16(2):225. doi: 10.3390/ph16020225. PMID: 37259373; PMCID: PMC9966414.

2: Badawi JK, Ding A, Bross S. Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle. Fundam Clin Pharmacol. 2008 Feb;22(1):75-86. doi: 10.1111/j.1472-8206.2007.00558.x. PMID: 18251724.

3: Jansen-Olesen I, Mortensen CH, El-Bariaki N, Ploug KB. Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression. Eur J Pharmacol. 2005 Oct 31;523(1-3):109-18. doi: 10.1016/j.ejphar.2005.08.028. Epub 2005 Oct 13. PMID: 16226739.

4: Pinna C, Sanvito P, Bolego C, Cignarella A, Puglisi L. Effect of the ATP- sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur J Pharmacol. 2005 May 23;516(1):71-7. doi: 10.1016/j.ejphar.2005.04.011. PMID: 15913601.

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