WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556329
CAS#: 169675-08-5 (free base)
Description: Ro60-0175 is a potent and selective SR-2 agonist. It shows selectivity for the 5-HT2C subtype (pKi values are 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). Ro60-0175 acts as a potent and selective agonist for both the 5-HT2B and 5-HT2C serotonin receptor subtypes, with good selectivity over the closely related 5-HT2A subtype, and little or no affinity at other receptors.
MedKoo Cat#: 556329
Name: Ro60-0175 free base
CAS#: 169675-08-5 (free base)
Chemical Formula: C11H12ClFN2
Exact Mass: 226.0673
Molecular Weight: 226.6794
Elemental Analysis: C, 58.29; H, 5.34; Cl, 15.64; F, 8.38; N, 12.36
Related CAS #: 169675-09-6 (fumarate) 169675-08-5 (free base)
Synonym: Ro60-0175; Ro-60-0175; Ro 60-0175; Ro600175; Ro-600175; Ro 600175;
IUPAC/Chemical Name: (S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine
InChi Key: XJJZQXUGLLXTHO-ZETCQYMHSA-N
InChi Code: InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
SMILES Code: C[C@H](N)CN1C=CC2=C1C=C(Cl)C(F)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 226.6794 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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