WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556234
CAS#: 852146-73-7
Description: KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM). It restores cardiac contractile function ex vivo in an isolated ischemic rat heart model when used at a concentration of 10 μM. KR-32568 may exert potent cardioprotective effects in rats via inhibition of sodium/hydrogen exchanger-1.
MedKoo Cat#: 556234
Name: KR-32568
CAS#: 852146-73-7
Chemical Formula: C13H12FN3O2
Exact Mass: 261.0914
Molecular Weight: 261.2564
Elemental Analysis: C, 59.77; H, 4.63; F, 7.27; N, 16.08; O, 12.25
Synonym: KR-32568; KR 32568; KR32568;
IUPAC/Chemical Name: N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-2-furancarboxamide
InChi Key: DTLDHYBZLVASJQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
SMILES Code: O=C(C1=CC=C(C2=CC(F)=CC=C2C)O1)NC(N)=N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 261.2564 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Li W, Ward R, Dong G, Ergul A, O'Connor P. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142. PMID: 31250553; PMCID: PMC6597793.
2: Tang Q, Ma J, Zhang P, Wan W, Kong L, Wu L. Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytes. Pflugers Arch. 2012 Apr;463(4):513-22. doi: 10.1007/s00424-011-1070-y. Epub 2012 Jan 11. PMID: 22234427.
3: Hu LF, Li Y, Neo KL, Yong QC, Lee SW, Tan BK, Bian JS. Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. J Pharmacol Exp Ther. 2011 Nov;339(2):726-35. doi: 10.1124/jpet.111.184754. Epub 2011 Aug 24. PMID: 21865440.
4: Roh HY, Jung IS, Park JW, Yun YP, Yi KY, Yoo SE, Kwon SH, Chung HJ, Shin HS. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. doi: 10.1159/000086192. Epub 2005 Jun 2. PMID: 15942274.
