KR-32568 | CAS#852146-73-7 | NHE-1 inhibitor

KR-32568
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556234

CAS#: 852146-73-7

Description: KR-32568 is an inhibitor of the sodium-hydrogen exchanger isoform-1 (NHE-1; IC50 = 230 nM). It restores cardiac contractile function ex vivo in an isolated ischemic rat heart model when used at a concentration of 10 μM. KR-32568 may exert potent cardioprotective effects in rats via inhibition of sodium/hydrogen exchanger-1.

Chemical Structure

KR-32568

CAS# 852146-73-7

Instruction

Theoretical Analysis

MedKoo Cat#: 556234
Name: KR-32568
CAS#: 852146-73-7
Chemical Formula: C13H12FN3O2
Exact Mass: 261.09
Molecular Weight: 261.256
Elemental Analysis: C, 59.77; H, 4.63; F, 7.27; N, 16.08; O, 12.25

Price and Availability

Size	Price	Availability
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3650	2 Weeks
2g	USD 6150	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: KR-32568; KR 32568; KR32568;

IUPAC/Chemical Name: N-(aminoiminomethyl)-5-(5-fluoro-2-methylphenyl)-2-furancarboxamide

InChi Key: DTLDHYBZLVASJQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)

SMILES Code: O=C(C1=CC=C(C2=CC(F)=CC=C2C)O1)NC(N)=N

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 261.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li W, Ward R, Dong G, Ergul A, O'Connor P. Neurovascular protection in voltage-gated proton channel Hv1 knock-out rats after ischemic stroke: interaction with Na+ /H+ exchanger-1 antagonism. Physiol Rep. 2019 Aug;7(13):e14142. doi: 10.14814/phy2.14142. PMID: 31250553; PMCID: PMC6597793.

2: Tang Q, Ma J, Zhang P, Wan W, Kong L, Wu L. Persistent sodium current and Na+/H+ exchange contributes to the augmentation of the reverse Na+/Ca2+ exchange during hypoxia or acute ischemia in ventricular myocytes. Pflugers Arch. 2012 Apr;463(4):513-22. doi: 10.1007/s00424-011-1070-y. Epub 2012 Jan 11. PMID: 22234427.

3: Hu LF, Li Y, Neo KL, Yong QC, Lee SW, Tan BK, Bian JS. Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. J Pharmacol Exp Ther. 2011 Nov;339(2):726-35. doi: 10.1124/jpet.111.184754. Epub 2011 Aug 24. PMID: 21865440.

4: Roh HY, Jung IS, Park JW, Yun YP, Yi KY, Yoo SE, Kwon SH, Chung HJ, Shin HS. Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury. Pharmacology. 2005 Dec;75(1):37-44. doi: 10.1159/000086192. Epub 2005 Jun 2. PMID: 15942274.

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