WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556322
CAS#: 2225800-19-9
Description: PUM00199, also known as PARP10-IN-3, is a selective mono‐ADP‐ribosyltransferase PARP10 inhibitor with an IC50 of 480 nM for human PARP10. This compound was first reported in Bioorganic & Medicinal Chemistry Letters (2018), 28(11), 2050-2054. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556322
Name: PUM00199
CAS#: 2225800-19-9
Chemical Formula: C14H12N2O3
Exact Mass: 256.0848
Molecular Weight: 256.261
Elemental Analysis: C, 65.62; H, 4.72; N, 10.93; O, 18.73
Synonym: PARP10-IN-3; PUM00199; PUM-00199; PUM 00199;
IUPAC/Chemical Name: 3-(4-carbamoylphenoxy)benzamide
InChi Key: PMOXYDXLQIUWHL-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H12N2O3/c15-13(17)9-4-6-11(7-5-9)19-12-3-1-2-10(8-12)14(16)18/h1-8H,(H2,15,17)(H2,16,18)
SMILES Code: O=C(C1=CC=C(C=C1)OC2=CC=CC(C(N)=O)=C2)N
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 256.261 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Holechek J, Lease R, Thorsell AG, Karlberg T, McCadden C, Grant R, Keen A, Callahan E, Schüler H, Ferraris D. Design, synthesis and evaluation of potent and selective inhibitors of mono-(ADP-ribosyl)transferases PARP10 and PARP14. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2050-2054. doi: 10.1016/j.bmcl.2018.04.056. Epub 2018 May 3. PMID: 29748053.
