WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556223
CAS#: 2387524-59-4
Description: SUN24595, also known as NF-κΒ activator 1, is a potent NF-κΒ activator with an EC50 of 0.9 μM. SUN24595 induces superoxide dismutase (SOD)2 mRNA expression. SUN24595 was first reported in European Journal of Medicinal Chemistry (2021), 210, 112952. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556223
Name: SUN24595
CAS#: 2387524-59-4
Chemical Formula: C16H11FN2O2S
Exact Mass: 314.0525
Molecular Weight: 314.3344
Elemental Analysis: C, 61.14; H, 3.53; F, 6.04; N, 8.91; O, 10.18; S, 10.20
Synonym: NF-κΒ activator 1; SUN24595; SUN-24595; SUN 24595;
IUPAC/Chemical Name: 3-(2-((2-fluorophenyl)amino)thiazol-4-yl)benzoic acid
InChi Key: SSUFECODNVILSX-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H11FN2O2S/c17-12-6-1-2-7-13(12)18-16-19-14(9-22-16)10-4-3-5-11(8-10)15(20)21/h1-9H,(H,18,19)(H,20,21)
SMILES Code: O=C(O)C1=CC=CC(C2=CSC(NC3=CC=CC=C3F)=N2)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 314.3344 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Mathew B, et al. Structure-activity relationship (SAR) studies of N-(3-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952 [Content Brief]
