MedKoo Biosciences

SLU-PP-332
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130437

CAS#: 303760-60-3

Description: SLU-PP-332, a ERR pan agonist with the highest affinity for ERRα, has been shown to lead to the increase of mitochondrial function and cellular respiration in a specific skeletal muscle cell line. SLU-PP-332 paves the way for the development of new molecules targeting the ERRα for the treatment of metabolic disorder and serving as a way to improve muscle function in aging.

Chemical Structure

SLU-PP-332

CAS# 303760-60-3

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 130437
Name: SLU-PP-332
CAS#: 303760-60-3
Chemical Formula: C18H14N2O2
Exact Mass: 290.11
Molecular Weight: 290.320
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 74.47; H, 4.86; N, 9.65; O, 11.02

Price and Availability

Size	Price	Availability
10mg	USD 150	Ready to ship
25mg	USD 250	Ready to ship
50mg	USD 450	Ready to ship
100mg	USD 750	Ready to ship
200mg	USD 1250	Ready to ship
500mg	USD 2650	Ready to ship
1g	USD 4250	Ready to ship
2g	USD 6450	Ready to ship
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: SLU-PP-332; SLU PP 332

IUPAC/Chemical Name: (E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide

InChi Key: RNZIMBFHRXYRLL-XDHOZWIPSA-N

InChi Code: InChI=1S/C18H14N2O2/c21-17-9-7-15(8-10-17)18(22)20-19-12-13-5-6-14-3-1-2-4-16(14)11-13/h1-12,21H,(H,20,22)/b19-12+

SMILES Code: O=C(N/N=C/C1=CC=C2C=CC=CC2=C1)C3=CC=C(O)C=C3

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Certificate of Analysis:

View CoA: current batch, Lot#A23T09K23

QC Data:

View QC data: current batch, Lot#A23T09K23

Safety Data Sheet (SDS):

View Safety Data Sheet (SDS)

Instruction:

View handling instruction

Biological target:	SLU-PP-332 is a pan- ERR agonist with EC50 values of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, respectively. SLUPP-332 enhances mitochondrial function and cellular respiration in skeletal muscle cell lines.
In vitro activity:	To be determined
In vivo activity:	SLU-PP-332, may offer a promising approach for treating metabolic syndrome and obesity. When administered to diet-induced obese or ob/ob mice, SLU-PP-332 mimicked the beneficial effects of exercise, leading to increased energy expenditure, enhanced fatty acid oxidation, and reduced fat mass accumulation. Furthermore, it improved insulin sensitivity in models of metabolic syndrome. Reference: J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. https://pubmed.ncbi.nlm.nih.gov/37739806/

Preparing Stock Solutions

The following data is based on the product molecular weight 290.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. doi: 10.1124/jpet.123.001733. Epub ahead of print. PMID: 37739806. 2. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.
In vitro protocol:	To be determined
In vivo protocol:	1. Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, Walker JK, Burris TP. A Synthetic ERR Agonist Alleviates Metabolic Syndrome. J Pharmacol Exp Ther. 2023 Sep 22:JPET-AR-2023-001733. doi: 10.1124/jpet.123.001733. Epub ahead of print. PMID: 37739806. 2. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1. Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W, Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity. ACS Chem Biol. 2023 Apr 21;18(4):756-771. doi: 10.1021/acschembio.2c00720. Epub 2023 Mar 29. PMID: 36988910.

2. https://www.ahajournals.org/doi/10.1161/circ.144.suppl_1.9682

3. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM4663186

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