WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 123206


Description: V2043, also known as ODBG-P-RVn, is a GS-441524 derivative, and an antiviral agent as a potential oral treatment for SARS-CoV-2. V2043 showed that it inhibits SARS-CoV-2 replication in Huh7.5 cells (EC50 = 138 nM) and is orally bioavailable in Syrian hamsters

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 123206
Name: V2043
Chemical Formula: C40H62N5O9P
Exact Mass: 787.43
Molecular Weight: 787.94
Elemental Analysis: C, 60.97; H, 7.93; N, 8.89; O, 18.27; P, 3.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: V2043; V 2043; V-2043; ODBG P-RVn; ODBG-P-RVn; ODBG-P RVn; C000718607

IUPAC/Chemical Name: ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((R)-2-(benzyloxy)-3-(octadecyloxy)propyl) hydrogen phosphate


InChi Code: InChI=1S/C40H62N5O9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-25-50-27-33(51-26-32-21-18-17-19-22-32)28-52-55(48,49)53-29-35-37(46)38(47)40(30-41,54-35)36-24-23-34-39(42)43-31-44-45(34)36/h17-19,21-24,31,33,35,37-38,46-47H,2-16,20,25-29H2,1H3,(H,48,49)(H2,42,43,44)/t33-,35-,37-,38-,40+/m1/s1


Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 787.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N,
Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou C. Broad-spectrum in vitro
antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified
monophosphate prodrug of remdesivir parent nucleoside (GS-441524). bioRxiv
[Preprint]. 2021 Aug 10:2021.08.06.455494. doi: 10.1101/2021.08.06.455494.
Update in: Microbiol Spectr. 2021 Nov 24;:e0153721. PMID: 34401879; PMCID:

2: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N,
Murphy J, Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou CF. Broad-
Spectrum <i>In Vitro</i> Antiviral Activity of ODBG-P-RVn: An Orally-Available,
Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside
(GS-441524). Microbiol Spectr. 2021 Dec 22;9(3):e0153721. doi:
10.1128/Spectrum.01537-21. Epub 2021 Nov 24. PMID: 34817209; PMCID: PMC8612139.