WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556217

CAS#: 2477651-10-6

Description: DUN51106, also known as USP8-IN-3, is a deubiquitinase USP8 inhibitor (IC50 = 4.0 μM) for treatment of malignant tumors. This compound was first reported in patent CN111138358. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CAS# 2477651-10-6

Theoretical Analysis

MedKoo Cat#: 556217
Name: DUN51106
CAS#: 2477651-10-6
Chemical Formula: C18H18F3N5O2S
Exact Mass: 425.11
Molecular Weight: 425.430
Elemental Analysis: C, 50.82; H, 4.26; F, 13.40; N, 16.46; O, 7.52; S, 7.54

Price and Availability

Size Price Availability Quantity
100mg USD 1250 2 Weeks
500mg USD 2850 2 Weeks
1g USD 4250 2 Weeks
2g USD 7250 2 Weeks
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Synonym: USP8-IN-3; DUN51106; DUN-51106; DUN 51106;

IUPAC/Chemical Name: 1-(4-nitrophenyl)-3-(1-(6-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)thiourea


InChi Code: InChI=1S/C18H18F3N5O2S/c19-18(20,21)15-2-1-3-16(24-15)25-10-8-13(9-11-25)23-17(29)22-12-4-6-14(7-5-12)26(27)28/h1-7,13H,8-11H2,(H2,22,23,29)

SMILES Code: [O-][N+](C1=CC=C(NC(NC2CCN(CC2)C3=CC=CC(C(F)(F)F)=N3)=S)C=C1)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 425.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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