WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 123094
CAS#: 1313731-99-5
Description: TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor
MedKoo Cat#: 123094
Name: TGN-020 sodium
CAS#: 1313731-99-5
Chemical Formula: C8H5N4NaOS
Exact Mass: 228.01
Molecular Weight: 228.2
Elemental Analysis: C, 42.11; H, 2.21; N, 24.55; Na, 10.07; O, 7.01; S, 14.05
Synonym: TGN-020 sodium; CID 139592827; TGN020 sodium; TGN-020;
IUPAC/Chemical Name: sodium nicotinoyl(1,3,4-thiadiazol-2-yl)amide
InChi Key: YVHWOCDMDRVSHB-UHFFFAOYSA-M
InChi Code: InChI=1S/C8H6N4OS.Na/c13-7(6-2-1-3-9-4-6)11-8-12-10-5-14-8;/h1-5H,(H,11,12,13);/q;+1/p-1
SMILES Code: O=C([N-]C1=NN=CS1)C2=CC=CN=C2.[Na+]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 228.2 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Chiang PP, Kuo SP, Newman EA. Cellular mechanisms mediating activity-
dependent extracellular space shrinkage in the retina. Glia. 2022
Oct;70(10):1927-1937. doi: 10.1002/glia.24228. Epub 2022 Jun 9. PMID: 35678626;
PMCID: PMC9378592.
