YAN50563
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MedKoo CAT#: 123002

CAS#: 2504950-56-3

Description: Also known as Me VH 032, amine. It is a derivative of the von Hippel-Lindau (VHL) ligand, VH 032 for use as a precursor to a PROTAC that hijacks VHL as the E3 ubiquitin ligase component.


Chemical Structure

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YAN50563
CAS# 2504950-56-3

Theoretical Analysis

MedKoo Cat#: 123002
Name: YAN50563
CAS#: 2504950-56-3
Chemical Formula: C23H34Cl2N4O3S
Exact Mass: 516.17
Molecular Weight: 517.510
Elemental Analysis: C, 53.38; H, 6.62; Cl, 13.70; N, 10.83; O, 9.27; S, 6.20

Price and Availability

Size Price Availability Quantity
100mg USD 750 2 Weeks
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Synonym: Me VH 032, amine; E3 ligase Ligand 1 dihydrochloride; VHL ligand 2 dihydrochloride; AMY27708

IUPAC/Chemical Name: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide dihydrochloride

InChi Key: YTJDUDNKHHNDRD-ARZBPYMHSA-N

InChi Code: InChI=1S/C23H32N4O3S.2ClH/c1-13(15-6-8-16(9-7-15)19-14(2)25-12-31-19)26-21(29)18-10-17(28)11-27(18)22(30)20(24)23(3,4)5;;/h6-9,12-13,17-18,20,28H,10-11,24H2,1-5H3,(H,26,29);2*1H/t13-,17+,18-,20+;;/m0../s1

SMILES Code: CC1=C(C2=CC=C(C=C2)[C@H](C)NC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 517.510000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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