WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556213
Description: CUN11141, also known as BRD4 Inhibitor-20, is a potent orally active bromodomain protein 4 (BRD4) inhibitor. It can be used for the research of kinds of cancer, such as colon cancer. This compound was first reported in European Journal of Medicinal Chemistry (2020), 208, 112780. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556213
Chemical Formula: C18H18N2O4S
Exact Mass: 358.0987
Molecular Weight: 358.412
Elemental Analysis: C, 60.32; H, 5.06; N, 7.82; O, 17.86; S, 8.95
Synonym: BRD4 Inhibitor-20 ; CUN11141; CUN-11141; CUN 11141;
IUPAC/Chemical Name: Benzenesulfonamide, N-[2,3-dihydro-3-(1-methylethylidene)-2-oxo-1H-indol-5-yl]-2-methoxy-
InChi Key: CDERLIUJSXSXFH-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H18N2O4S/c1-11(2)17-13-10-12(8-9-14(13)19-18(17)21)20-25(22,23)16-7-5-4-6-15(16)24-3/h4-10,20H,1-3H3,(H,19,21)
SMILES Code: O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(/C3=C(C)/C)=O)C=C2)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 358.412 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Xu Y, Zhang XJ, Li WB, Wang XR, Wang S, Qiao XP, Chen SW. Design, synthesis and biological evaluation of indole-2-one derivatives as potent BRD4 inhibitors. Eur J Med Chem. 2020 Dec 15;208:112780. doi: 10.1016/j.ejmech.2020.112780. Epub 2020 Aug 30. PMID: 32883643.