WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 556212

CAS#: 2641826-39-1

Description: ZVN26391, also known as NLRP3-IN-10, is a IL-1β inhibitor for the treatment of inflammation and inflammation-related disease (neurogenic inflammation, Alzheimer disease, etc.). This compound was reported in patent CN112745284. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).

Chemical Structure

CAS# 2641826-39-1

Theoretical Analysis

MedKoo Cat#: 556212
Name: ZVN26391
CAS#: 2641826-39-1
Chemical Formula: C17H14BrFO3
Exact Mass: 364.01
Molecular Weight: 365.198
Elemental Analysis: C, 55.91; H, 3.86; Br, 21.88; F, 5.20; O, 13.14

Price and Availability

Size Price Availability Quantity
100mg USD 1450 2 Weeks
1g USD 4250 2 Weeks
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Synonym: NLRP3-IN-10; ZVN26391; ZVN-26391; ZVN 26391;

IUPAC/Chemical Name: (E)-3-(4-bromo-2,5-dimethoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one


InChi Code: InChI=1S/C17H14BrFO3/c1-21-16-10-14(18)17(22-2)9-12(16)5-8-15(20)11-3-6-13(19)7-4-11/h3-10H,1-2H3/b8-5+

SMILES Code: BrC(C=C1OC)=C(C=C1/C=C/C(C2=CC=C(C=C2)F)=O)OC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 365.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Preparation of chalcone derivatives useful a IL-1β inhibitor for the treatment of inflammation
By: Wu, Wenshuang; Zhang, Ruijia; Ye, Haoyu
China, CN112745284 A 2021-05-04