WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556212
CAS#: 2641826-39-1
Description: ZVN26391, also known as NLRP3-IN-10, is a IL-1β inhibitor for the treatment of inflammation and inflammation-related disease (neurogenic inflammation, Alzheimer disease, etc.). This compound was reported in patent CN112745284. This product has no formal name at the moment. For the convenience of communication, a temporal code name was therefore proposed according to MedKoo Chemical Nomenclature (see web page: https://www.medkoo.com/page/naming).
MedKoo Cat#: 556212
Name: ZVN26391
CAS#: 2641826-39-1
Chemical Formula: C17H14BrFO3
Exact Mass: 364.011
Molecular Weight: 365.1984
Elemental Analysis: C, 55.91; H, 3.86; Br, 21.88; F, 5.20; O, 13.14
Synonym: NLRP3-IN-10; ZVN26391; ZVN-26391; ZVN 26391;
IUPAC/Chemical Name: (E)-3-(4-bromo-2,5-dimethoxyphenyl)-1-(4-fluorophenyl)prop-2-en-1-one
InChi Key: ZXMIFRJYIRYWTC-VMPITWQZSA-N
InChi Code: InChI=1S/C17H14BrFO3/c1-21-16-10-14(18)17(22-2)9-12(16)5-8-15(20)11-3-6-13(19)7-4-11/h3-10H,1-2H3/b8-5+
SMILES Code: BrC(C=C1OC)=C(C=C1/C=C/C(C2=CC=C(C=C2)F)=O)OC
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 365.1984 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Preparation of chalcone derivatives useful a IL-1β inhibitor for the treatment of inflammation
By: Wu, Wenshuang; Zhang, Ruijia; Ye, Haoyu
China, CN112745284 A 2021-05-04
