WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 556209
CAS#: 692870-25-0
Description: WAY-658513 is a multiple kinase inhbitor. WAY658513 was shown to inhibit ROCK I, ERK2, GSK3, and PKA with Ki <1 μM. WAY-658513 was first reported in patent WO2004041813
MedKoo Cat#: 556209
Name: WAY-658513
CAS#: 692870-25-0
Chemical Formula: C16H11ClFN3OS
Exact Mass: 347.0295
Molecular Weight: 347.7924
Elemental Analysis: C, 55.26; H, 3.19; Cl, 10.19; F, 5.46; N, 12.08; O, 4.60; S, 9.22
Synonym: WAY-658513; WAY 658513; WAY658513;
IUPAC/Chemical Name: Benzeneacetamide, 2-chloro-6-fluoro-N-[4-(4-pyridinyl)-2-thiazolyl]-
InChi Key: BPGUVXHQHDKSTA-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H11ClFN3OS/c17-12-2-1-3-13(18)11(12)8-15(22)21-16-20-14(9-23-16)10-4-6-19-7-5-10/h1-7,9H,8H2,(H,20,21,22)
SMILES Code: O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=C(F)C=CC=C3Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 347.7924 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Preparation of thienyl- and thiazolecarboxamides as inhibitors of ROCK, ERK, GSK, and AGC protein kinases
By: Cao, Jingrong; Gao, Huai; Green, Jeremy; Marhefka, Craig
World Intellectual Property Organization, WO2004041813 A1 2004-05-21 | Language: English, Database: CAplus
