WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 130258


Description: GD433 is a NTMT1 chemical probe for in vivo use.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 130258
Name: GD433
Chemical Formula: C20H24FN3O3S
Exact Mass: 405.15
Molecular Weight: 405.488
Elemental Analysis: C, 59.24; H, 5.97; F, 4.69; N, 10.36; O, 11.84; S, 7.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Synonym: GD433; GD 433; GD-433

IUPAC/Chemical Name: (S)-quinuclidin-3-yl (2-(2-(4-fluoro-3-hydroxyphenyl)thiazol-4-yl)propan-2-yl)carbamate


InChi Code: InChI=1S/C20H24FN3O3S/c1-20(2,23-19(26)27-16-10-24-7-5-12(16)6-8-24)17-11-28-18(22-17)13-3-4-14(21)15(25)9-13/h3-4,9,11-12,16,25H,5-8,10H2,1-2H3,(H,23,26)/t16-/m1/s1

SMILES Code: O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C(O)=C4)=N3)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.488400000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Deng Y, Dong G, Meng Y, Noinaj N, Huang R. Structure-Activity Relationship Studies of Venglustat on NTMT1 Inhibition. J Med Chem. 2023 Jan 26;66(2):1601-1615. doi: 10.1021/acs.jmedchem.2c01854. Epub 2023 Jan 12. PMID: 36634151; PMCID: PMC9892271.