WJM-921

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122818

CAS#: N/A

Description: WJM-921 is a PfATP4 inhibitor with EC50= 8 nM. WJM-921 demonstrates oral efficacy in a mouse model of malaria.


Chemical Structure

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WJM-921
CAS# N/A

Theoretical Analysis

MedKoo Cat#: 122818
Name: WJM-921
CAS#: N/A
Chemical Formula: C18H14Cl2N4O3
Exact Mass: 404.04
Molecular Weight: 405.240
Elemental Analysis: C, 53.35; H, 3.48; Cl, 17.50; N, 13.83; O, 11.84

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: WJM-921; WJM921; WJM 921

IUPAC/Chemical Name: (R)-8-chloro-N-(5-chloropyridin-3-yl)-4-methyl-1,5-dioxo-2,3,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a(1H)-carboxamide

InChi Key: CSHDBBLSXAAVQZ-GOSISDBHSA-N

InChi Code: InChI=1S/C18H14Cl2N4O3/c1-23-16(26)13-3-2-10(19)7-14(13)24-15(25)4-5-18(23,24)17(27)22-12-6-11(20)8-21-9-12/h2-3,6-9H,4-5H2,1H3,(H,22,27)/t18-/m1/s1

SMILES Code: ClC1=CC(N(C(CC2)=O)[C@]2(C(NC3=CC(Cl)=CN=C3)=O)N(C)C4=O)=C4C=C1

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Ashton TD, Dans MG, Favuzza P, Ngo A, Lehane AM, Zhang X, Qiu D, Chandra Maity B, De N, Schindler KA, Yeo T, Park H, Uhlemann AC, Churchyard A, Baum J, Fidock DA, Jarman KE, Lowes KN, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4. J Med Chem. 2023 Feb 22. doi: 10.1021/acs.jmedchem.2c02092. Epub ahead of print. PMID: 36812492.