WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 130105
Description: GBLI-2 serves as a bioluminescence probe for imaging of tumors, specifically granzyme B activity, during immunotherapy treatments. GBLI-2 consists of the mouse granzyme B tetrapeptide IEFD substrate that, through a self-immolative group, was conjugated to D-luciferin. For CT26 murine colorectal carcinoma in mice, GBLI-2 successfully correlated to the amount/level of granzyme B-expressing CD8+ T cells in tumors.
MedKoo Cat#: 130105
Chemical Formula: C45H51N7O12S2
Exact Mass: 945.3037
Molecular Weight: 946.06
Elemental Analysis: C, 57.13; H, 5.43; N, 10.36; O, 20.29; S, 6.78
This product is not in stock, which may be available by custom synthesis.
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Synonym: GBLI-2; GBLI2; GBLI 2
IUPAC/Chemical Name: (S)-2-(6-((4-((2S,5S,8S,11R)-5-Benzyl-11-((R)-sec-butyl)-2,8-bis(2-carboxyethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazatetradecanamido)benzyl)oxy)benzo[d]thiazol-2-yl)-4,5-dihydrothiazole-4-carboxylic acid
InChi Key: GVYPBXALQZYEPR-AZAFZZPZSA-N
InChi Code: InChI=1S/C45H51N7O12S2/c1-4-24(2)38(46-25(3)53)42(61)49-32(17-19-37(56)57)40(59)50-33(20-26-8-6-5-7-9-26)41(60)48-31(16-18-36(54)55)39(58)47-28-12-10-27(11-13-28)22-64-29-14-15-30-35(21-29)66-44(51-30)43-52-34(23-65-43)45(62)63/h5-15,21,24,31-34,38H,4,16-20,22-23H2,1-3H3,(H,46,53)(H,47,58)(H,48,60)(H,49,61)(H,50,59)(H,54,55)(H,56,57)(H,62,63)/t24-,31+,32+,33+,34-,38-/m1/s1
SMILES Code: O=C([C@@H]1N=C(C2=NC3=CC=C(OCC4=CC=C(NC([C@H](CCC(O)=O)NC([C@H](CC5=CC=CC=C5)NC([C@H](CCC(O)=O)NC([C@@H]([C@H](C)CC)NC(C)=O)=O)=O)=O)=O)C=C4)C=C3S2)SC1)O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 946.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Chen M, Zhou K, Dai SY, Tadepalli S, Balakrishnan PB, Xie J, Rami FEI, Dai T, Cui L, Idoyaga J, Rao J. In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy. Cell Chem Biol. 2022 Oct 20;29(10):1556-1567.e6. doi: 10.1016/j.chembiol.2022.08.006. Epub 2022 Sep 13. PMID: 36103874; PMCID: PMC9588750.