BAY1125976 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 206151

CAS#: 1402608-02-9 (free base)

Description: BAY1125976 is an orally bioavailable inhibitor of the serine/threonine protein kinase AKT (protein kinase B) isoforms 1 and 2 (AKT1/2) with potential antineoplastic activity. AKT1/2 inhibitor BAY1125976 selectively binds to and inhibits the phosphorylation and activity of AKT1/2 in a non-ATP competitive manner, which may result in the inhibition of the phosphatidylinositol 3 (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway. This may lead to both the reduction of cell proliferation and the induction of cell apoptosis in AKT-overexpressing tumor cells. The AKT signaling pathway is often deregulated in cancer and is associated with tumor cell proliferation, survival and migration.


Price and Availability

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BAY1125976 HCl, purity > 98%, is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 206151
Name: BAY1125976 HCl
CAS#: 1402608-02-9 (free base)
Chemical Formula: C23H23Cl2N5O
Exact Mass:
Molecular Weight: 456.371
Elemental Analysis: C, 60.53; H, 5.08; Cl, 15.54; N, 15.35; O, 3.51


Related CAS #: 1402608-02-9 (free base)   CAS# oif its HCl is unknown  

Synonym: BAY1125976; BAY 1125976; BAY-1125976; BAY1125976 HCl; BAY1125976 dihydrochloride; BAY1125976 hydrochloride;

IUPAC/Chemical Name: Imidazo[1,2-b]pyridazine-6-carboxamide, 2-[4-(1-aminocyclobutyl)phenyl]-3-phenyl- dihydrochloride

InChi Key: FQADVAXTTOAHES-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H21N5O.2ClH/c24-22(29)18-11-12-19-26-20(21(28(19)27-18)16-5-2-1-3-6-16)15-7-9-17(10-8-15)23(25)13-4-14-23;;/h1-3,5-12H,4,13-14,25H2,(H2,24,29);2*1H

SMILES Code: O=C(C1=NN2C(C=C1)=NC(C3=CC=C(C4(N)CCC4)C=C3)=C2C5=CC=CC=C5)N.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO, not in water

Shelf Life:
>2 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


Additional Information

  
 
 
 


References