WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 130030
CAS#: 1380329-87-2
Description: Gemlapodect is a phosphodiesterase 10A (PDE10A) inhibitor currently undergoing clinical trials for use as a treatment for Tourette's Syndrome by modulating the signaling of D2 receptors. PDE10A is highly expressed in striatal medium spiny neurons, with inhibition leading to behavioral and antipsychotic effects.
MedKoo Cat#: 130030
Name: Gemlapodect
CAS#: 1380329-87-2
Chemical Formula: C22H21N7O3
Exact Mass: 431.1706
Molecular Weight: 431.46
Elemental Analysis: C, 61.24; H, 4.91; N, 22.73; O, 11.12
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Synonym: Gemlapodect
IUPAC/Chemical Name: 1-methyl-4-[(morpholin-4-yl)carbonyl]-N-(2- phenyl[1,2,4]triazolo[1,5-a]pyridin-7-yl)-1H-pyrazole-5- carboxamide
InChi Key: MMCSMWHWVGGCGL-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H21N7O3/c1-27-19(17(14-23-27)22(31)28-9-11-32-12-10-28)21(30)24-16-7-8-29-18(13-16)25-20(26-29)15-5-3-2-4-6-15/h2-8,13-14H,9-12H2,1H3,(H,24,30)
SMILES Code: O=C(C1=C(C(N2CCOCC2)=O)C=NN1C)NC3=CC4=NC(C5=CC=CC=C5)=NN4C=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 431.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Menniti FS, Chappie TA, Schmidt CJ. PDE10A Inhibitors-Clinical Failure or Window Into Antipsychotic Drug Action? Front Neurosci. 2021 Jan 20;14:600178. doi: 10.3389/fnins.2020.600178. PMID: 33551724; PMCID: PMC7855852.
