WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 122631


Description: Y08197 is a CBP/P300 BRD inhibitor

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 122631
Name: Y08197
Chemical Formula: C23H21FN4O4
Exact Mass: 436.15
Molecular Weight: 436.440
Elemental Analysis: C, 63.30; H, 4.85; F, 4.35; N, 12.84; O, 14.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Y08197; Y 08197; Y-08197

IUPAC/Chemical Name: 3-acetyl-N-(2-fluoro-5-(hydroxymethyl)-3-(1-methyl-1H-pyrazol-4-yl)phenyl)-7-methoxyindolizine-1-carboxamide


InChi Code: InChI=1S/C23H21FN4O4/c1-13(30)20-9-18(21-8-16(32-3)4-5-28(20)21)23(31)26-19-7-14(12-29)6-17(22(19)24)15-10-25-27(2)11-15/h4-11,29H,12H2,1-3H3,(H,26,31)

SMILES Code: COC(C=CN1C(C(C)=O)=C2)=CC1=C2C(NC3=CC(CO)=CC(C4=CN(C)N=C4)=C3F)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 436.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Akinsiku OE, Soremekun OS, Olotu FA, Soliman MES. Exploring the Role of
Asp1116 in Selective Drug Targeting of CREBcAMP- Responsive Element-binding
Protein Implicated in Prostate Cancer. Comb Chem High Throughput Screen.
2020;23(3):178-184. doi: 10.2174/1386207323666200219122057. PMID: 32072894.

2: Zou LJ, Xiang QP, Xue XQ, Zhang C, Li CC, Wang C, Li Q, Wang R, Wu S, Zhou
YL, Zhang Y, Xu Y. Y08197 is a novel and selective CBP/EP300 bromodomain
inhibitor for the treatment of prostate cancer. Acta Pharmacol Sin. 2019
Nov;40(11):1436-1447. doi: 10.1038/s41401-019-0237-5. Epub 2019 May 16. PMID:
31097763; PMCID: PMC6889168.